Recurrence of membranoproliferative glomerulonephritis post transplant is this mere recurrence of pattern or recurrence of disease ?
المؤلفون المشاركون
Lingaraj, Umaysh
Vankalakunti, Maheshas
Mallappa, Shivaprasad Sasivehalli
Gurusiddaiah, Sreedhara Chikkanayakanahalli
Patil, Shivanagouda Ramanagouda
Aralapuram, Kishan
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 30، العدد 3 (30 يونيو/حزيران 2019)، ص ص. 719-722، 4ص.
الناشر
تاريخ النشر
2019-06-30
دولة النشر
السعودية
عدد الصفحات
4
التخصصات الرئيسية
الموضوعات
الملخص EN
Recurrence of membranoproliferative glomerulonephritis (MPGN) is seen in 19– 65% cases of postrenal transplant resulting in graft loss in up to 35–50% of cases.
A 31-year-old female, after 1½ years on maintenance hemodialysis, underwent ABO compatible deceased donor kidney transplantation with basiliximab induction.
During the immediate posttransplant period, the patient had delayed graft function, but achieved nadir creatinine of 0.9 mg/dL by 10 days.
Nine months posttransplant, the patient developed fever, anasarca, and decrease in urine output with albuminuria 3+, active sediments in urine, serum creatinine 3.5 mg/dL, 24-h urine protein 7.5 g, and low C3.
The patient underwent graft biopsy.
Subsequently, the patient received pulse steroid for three days and five sessions of plasmapheresis.
Renal biopsy report was suggestive of MPGN with focal crescents and acute tubular necrosis.
Immunofluorescence showed Ig G3+, C3 3+, 3+, and negative for or other immunoglobulins or complements.
As her native kidney disease was immune-complex-mediated MPGN with no light chain restriction, paraffin tissue of the native kidney was reexamined for light chain restrictions by immunoperoxidase method, but did not show light chain restriction.
The patient underwent extensive workup for paraproteinemias, but results were negative.
Subsequently, she received four doses of bortezomib.
The patient’s serum creatinine got reduced to 0.8 mg/dL and proteinuria reduced to 800 mg/day.
Our case is unique as we were not able to demonstrate monoclonal deposits in native kidney sample although there was recurrence of MPGN with monoclonal light chain deposits post transplant.
Our findings emphasize the need for thorough evaluation of paraproteinemias in patients with idiopathic MPGN even in the absence of light chain deposition in biopsy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lingaraj, Umaysh& Patil, Shivanagouda Ramanagouda& Aralapuram, Kishan& Mallappa, Shivaprasad Sasivehalli& Gurusiddaiah, Sreedhara Chikkanayakanahalli& Vankalakunti, Maheshas. 2019. Recurrence of membranoproliferative glomerulonephritis post transplant is this mere recurrence of pattern or recurrence of disease ?. Saudi Journal of Kidney Diseases and Transplantation،Vol. 30, no. 3, pp.719-722.
https://search.emarefa.net/detail/BIM-894169
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lingaraj, Umaysh…[et al.]. Recurrence of membranoproliferative glomerulonephritis post transplant is this mere recurrence of pattern or recurrence of disease ?. Saudi Journal of Kidney Diseases and Transplantation Vol. 30, no. 3 (May. / Jun. 2019), pp.719-722.
https://search.emarefa.net/detail/BIM-894169
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lingaraj, Umaysh& Patil, Shivanagouda Ramanagouda& Aralapuram, Kishan& Mallappa, Shivaprasad Sasivehalli& Gurusiddaiah, Sreedhara Chikkanayakanahalli& Vankalakunti, Maheshas. Recurrence of membranoproliferative glomerulonephritis post transplant is this mere recurrence of pattern or recurrence of disease ?. Saudi Journal of Kidney Diseases and Transplantation. 2019. Vol. 30, no. 3, pp.719-722.
https://search.emarefa.net/detail/BIM-894169
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 721-722
رقم السجل
BIM-894169
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر