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Synthesis, characterization and acute anti-inflammatory evaluation of new mefenamic acid derivatives having 4-thiazolidinone nucleus
العناوين الأخرى
تصنيع و تشخيص و التقييم المضاد للالتهاب الحاد لمشتقات جديدة لحمض الميفينامك مع نواة 4-ثيازوليدينون
المؤلفون المشاركون
al-Safi, Mustafa Husayn Ali
Farhan, Muthanna Sadi
المصدر
Iraqi Journal of Pharmaceutical Sciences
العدد
المجلد 28، العدد 1 (30 يونيو/حزيران 2019)، ص ص. 140-148، 9ص.
الناشر
تاريخ النشر
2019-06-30
دولة النشر
العراق
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Mefenamic acid (MA) widely used probably due to having both anti-inflammatory and analgesic activity, the main side effects of mefenamic acid include gastrointestinal tract (GIT) disturbance mainly diarrhea, peptic ulceration, and gastric bleeding.
The study aimed to synthesize derivatives of mefenamic acid with more potency and to decrease the drug's potential side effects, new series of 4-thiazolidinone derivatives of mefenamic acid were synthesized IVa-g.
The synthetic procedures for target compounds and their intermediates are designed to be as follows: acylation of secondary amine of mefenamic acid by chloroacetylchloride to produce compound (I), then reaction between compound (I) and hydrazine hydrate to produce compound (II).
After that, Schiff base formation by addition of seven benzaldehyde derivatives and finally, cyclization in presence of thioglycolic acid to form 4-thiazolidinone heterocyclic ring.
The characterization of the titled compounds has been established on the basis of their spectral FTIR, 1HNMR data, and by measurements of their physical properties.
In vivo acute anti-inflammatory effect of the synthesized compounds was evaluated in rats using egg-white (i.p) induced edema model of inflammation.
The tested compounds and the reference drug produced significant reduction of paw edema with respect to the effect of dimethyl sulfoxide 10%v/v (control group).
Compound IVe showed more potent effect than mefenamic acid at 240-300 min, while at time 300 min, compounds IVa and IVd exhibit more potent anti-inflammatory effect than mefenamic acid (50mg/kg, i.p.).
On the other hand compound IVc exhibited lower anti-inflammatory effect.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Safi, Mustafa Husayn Ali& Farhan, Muthanna Sadi. 2019. Synthesis, characterization and acute anti-inflammatory evaluation of new mefenamic acid derivatives having 4-thiazolidinone nucleus. Iraqi Journal of Pharmaceutical Sciences،Vol. 28, no. 1, pp.140-148.
https://search.emarefa.net/detail/BIM-894771
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Safi, Mustafa Husayn Ali& Farhan, Muthanna Sadi. Synthesis, characterization and acute anti-inflammatory evaluation of new mefenamic acid derivatives having 4-thiazolidinone nucleus. Iraqi Journal of Pharmaceutical Sciences Vol. 28, no. 1 (2019), pp.140-148.
https://search.emarefa.net/detail/BIM-894771
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Safi, Mustafa Husayn Ali& Farhan, Muthanna Sadi. Synthesis, characterization and acute anti-inflammatory evaluation of new mefenamic acid derivatives having 4-thiazolidinone nucleus. Iraqi Journal of Pharmaceutical Sciences. 2019. Vol. 28, no. 1, pp.140-148.
https://search.emarefa.net/detail/BIM-894771
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 147-148
رقم السجل
BIM-894771
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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