Spectrophotometric estimation of thiamine in tablet form application to content uniformity testing

العناوين الأخرى

تقدير الثيامين طيفيا في مستحضراته الصيدلانية : تطبيق الطريقة لاختبار الاتساق

المؤلفون المشاركون

al-Qazzaz, Wail A.
Ahmad, Nayif Rahman

المصدر

Rafidain Journal of Science

الناشر

جامعة الموصل كلية العلوم

تاريخ النشر

2019-04-30

دولة النشر

العراق

عدد الصفحات

6

التخصصات الرئيسية

الكيمياء

الموضوعات

• القياس
• مقاييس الطيف
• الأدوية
• فيتامين ب1

الملخص الإنجليزي

A simple, rapid, accurate and sensitive spectrophotometric method for the determination of thiamine has been developed.

The method is based on the direct reaction between thiamine and sodium hydroxide to produce a yellow colored product having maximum absorption at 335 nm.

Beer's law was obeyed over the concentration range of 2-20μg/ml,with molar absorptivity of 1.58x104 l/mol.cm.

The present method was considered to be simple because it does not need heating, hydrolysis and solvent extraction steps.

The ingredients often formulated with thiamine, have been shown not to interfere, and is suitable for the routine determination of thiamine.

The proposed method has been successfully applied for the determination of thiamine in pure form and in pharmaceutical preparations(tablets).

نوع البيانات

أوراق مؤتمرات

رقم السجل

BIM-895002

• APA
• MLA
• AMA