Efficacy and safety of an interferon-free regimen for treatment of recurrent hepatitis C virus infection following liver transplant
المؤلفون المشاركون
al-Rahim, Abir S. al-Din
Musa, Ahmad S. Abd al-Muhsin
Ahmad, Ahlam Muhammad
المصدر
Journal of Current Medical Research and Practice
العدد
المجلد 4، العدد 1 (30 إبريل/نيسان 2019)، ص ص. 11-17، 7ص.
الناشر
تاريخ النشر
2019-04-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Introduction Recurrent hepatitis C virus (HCV) infection after transplantation is aggressive, and its progression to cirrhosis is more rapid than in nontransplant settings.
As pegylated interferon based therapies for HCV treatment after transplantation have poor tolerance, poor efficacy, and significant interactions with immunosuppression medications, and this developed the need for a new safe and effective oral regimen.
Aim To evaluate the efficacy, safety, and tolerability of sofosbuvir (SOF) in combination with ribavirin (RBV) in treating recurrent hepatitis C after transplantation and also to detect any significant interaction with immunosuppressive therapy.
Patients and methods Between August 2014 and January 2016, a single‑center, prospective, nonrandomized, open‑labeled study was conducted, in which the patients with post‑transplant recurrent HCV infection were enrolled.
All patients received 400 mg once‑daily SOF for 24 weeks with variable dose of RBV.
After treatment, patients underwent follow‑up for 12 weeks.
Results Sixty patients were enrolled, and their mean age was 57.67 years, with 78.3% were male.
Overall, 70% had genotype 1 and 61.7% had received previous HCV treatment.
At baseline, 21 patients had severe fibrosis.
Median time interval from liver transplantation was 51 months, and immunosuppressive therapy was tacrolimus based in 78.3%.
Median baseline HCV‑RNA was 2.341.172 IU/ml.
Among the patients, 12‑week sustained virological response was achieved in 43 (71.7%) patients.
There was no significant difference in dose and level of tacrolimus during course of therapy.
Absence of hepatic encephalopathy, treatment‑naive patients, nonsevere fibrosis, and low pretherapy Liver stiffness (LS) values were predictors for sustained virological response.
Conclusion Interferon‑free regimen containing SOF and RBV is generally safe, well tolerated, and reasonably effective in post‑transplantation settings.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ahmad, Ahlam Muhammad& al-Rahim, Abir S. al-Din& Musa, Ahmad S. Abd al-Muhsin. 2019. Efficacy and safety of an interferon-free regimen for treatment of recurrent hepatitis C virus infection following liver transplant. Journal of Current Medical Research and Practice،Vol. 4, no. 1, pp.11-17.
https://search.emarefa.net/detail/BIM-895169
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ahmad, Ahlam Muhammad…[et al.]. Efficacy and safety of an interferon-free regimen for treatment of recurrent hepatitis C virus infection following liver transplant. Journal of Current Medical Research and Practice Vol. 4, no. 1 (Jan. / Apr. 2019), pp.11-17.
https://search.emarefa.net/detail/BIM-895169
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ahmad, Ahlam Muhammad& al-Rahim, Abir S. al-Din& Musa, Ahmad S. Abd al-Muhsin. Efficacy and safety of an interferon-free regimen for treatment of recurrent hepatitis C virus infection following liver transplant. Journal of Current Medical Research and Practice. 2019. Vol. 4, no. 1, pp.11-17.
https://search.emarefa.net/detail/BIM-895169
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 17
رقم السجل
BIM-895169
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر