Safety of sildenafil citrate in the management of hypertensive disorders of pregnancy
المؤلفون المشاركون
Kamil, Hasan S.
Abu Talib, Hisham A.
Abd Allah, Fadi N.
المصدر
Journal of Current Medical Research and Practice
العدد
المجلد 4، العدد 1 (30 إبريل/نيسان 2019)، ص ص. 50-55، 6ص.
الناشر
تاريخ النشر
2019-04-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective This study investigated the safety of sildenafil citrate in managing hypertensive disorders of pregnancy.
Patients and methods In a randomized, double‑blind, placebo‑controlled trial, 122 singleton pregnancies with mild pre‑eclampsia between 28 and 36 weeks of gestation were randomized to either use oral sildenafil citrate tablets with antihypertensive or antihypertensive alone.
The primary outcome was occurrence of maternal and/or neonatal complications.
Results Headache was the most frequent adverse effect in the study and is significantly higher in the intervention group [22 (36.1%) vs.
12 (19.7%) in placebo group; P = 0.03].
In the intervention group, headache was dose related.
The headache was tolerable in the majority of patients.
The intervention group has an insignificant lower incidence of intrauterine growth restriction than the placebo group (1.7 vs.
6.7%, respectively, P = 0.31).
The incidence of oligohydramnios was significantly higher in the placebo group than in the intervention group (16.7 vs.
8.5%, respectively, P = 0.03).
No intrauterine fetal deaths have occurred in our study, and only one neonatal death occurred in the placebo group.
Conclusion Using sildenafil citrate in addition to other antihypertensive drugs in the management of mild pre‑eclampsia is safe and has a better maternal and neonatal outcome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kamil, Hasan S.& Abu Talib, Hisham A.& Abd Allah, Fadi N.. 2019. Safety of sildenafil citrate in the management of hypertensive disorders of pregnancy. Journal of Current Medical Research and Practice،Vol. 4, no. 1, pp.50-55.
https://search.emarefa.net/detail/BIM-895246
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kamil, Hasan S.…[et al.]. Safety of sildenafil citrate in the management of hypertensive disorders of pregnancy. Journal of Current Medical Research and Practice Vol. 4, no. 1 (Jan. / Apr. 2019), pp.50-55.
https://search.emarefa.net/detail/BIM-895246
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kamil, Hasan S.& Abu Talib, Hisham A.& Abd Allah, Fadi N.. Safety of sildenafil citrate in the management of hypertensive disorders of pregnancy. Journal of Current Medical Research and Practice. 2019. Vol. 4, no. 1, pp.50-55.
https://search.emarefa.net/detail/BIM-895246
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 55
رقم السجل
BIM-895246
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر