Ciclosporin-induced accessory breast tissue : dramatic improvement after dose adjustment
المؤلفون المشاركون
Karra, Wiam Nabil Mahmud
al-Safi, Ala'a Abd Allah
Abbud, Umar Ibrahim
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 30، العدد 2 (30 إبريل/نيسان 2019)، ص ص. 513-515، 3ص.
الناشر
تاريخ النشر
2019-04-30
دولة النشر
السعودية
عدد الصفحات
3
التخصصات الرئيسية
الموضوعات
الملخص EN
Accessory breast tissue is a relatively common congenital condition in which abnormal accessory breast tissue is seen as a mass anywhere along the course of embryologic mammary streak in addition to the presence of normal breast tissue.
Ciclosporin therapy has been associated with benign breast disease in women.
However, to the best of our knowledge, there are no reported cases of accessory breast tissue growth associated with ciclosporin therapy and regression after adjusting the dose.
A 48-year-old woman had renal transplantation in 2009 with her brother as the donor.
Her transplant follow-up over eight years had been unremarkable.
She presented to our transplant follow-up clinic with bilateral painful axillary masses approximately 3 cm × 3 cm in diameter, not attached to the skin or underlying structures with no skin changes and no lymphadenopathy.
Breast examination did not reveal any abnormalities.
Her ciclosporin levels over the previous three years ranged between 130 and 150 ng/mL.
These levels were within the acceptable recommended level of 100–150 ng/mL at that time (currently reduced to 80–120 ng/ml).
Ultrasound of both axilla showed well-defined hypoechoic smooth outline masses in both axillary regions 3 cm × 4 cm.
Fine-needle aspiration showed lesions consisting of cohesive ductal cells.
The findings were consistent with accessory breast tissue with no evidence of inflammatory infiltrate or malignant changes.
Her ciclosporin dose was reduced with the subsequent follow-up visits levels ranging between 90 and 110 ng/mL.
Clinical examination four months later showed dramatic reduction in the axillary masses on both sides.
Ultrasound confirmed the regression in the size of both masses.
We conclude that ciclosporin was probably responsible for the formation of accessory breast tissue and reduction in the dose of ciclosporin resulted in substantial reduction in the tissue size.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Karra, Wiam Nabil Mahmud& al-Safi, Ala'a Abd Allah& Abbud, Umar Ibrahim. 2019. Ciclosporin-induced accessory breast tissue : dramatic improvement after dose adjustment. Saudi Journal of Kidney Diseases and Transplantation،Vol. 30, no. 2, pp.513-515.
https://search.emarefa.net/detail/BIM-895846
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Karra, Wiam Nabil Mahmud…[et al.]. Ciclosporin-induced accessory breast tissue : dramatic improvement after dose adjustment. Saudi Journal of Kidney Diseases and Transplantation Vol. 30, no. 2 (Mar. / Apr. 2019), pp.513-515.
https://search.emarefa.net/detail/BIM-895846
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Karra, Wiam Nabil Mahmud& al-Safi, Ala'a Abd Allah& Abbud, Umar Ibrahim. Ciclosporin-induced accessory breast tissue : dramatic improvement after dose adjustment. Saudi Journal of Kidney Diseases and Transplantation. 2019. Vol. 30, no. 2, pp.513-515.
https://search.emarefa.net/detail/BIM-895846
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 515
رقم السجل
BIM-895846
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر