Protective effect of pretreatment with calcium channel blockers on motor coordination deficit of mice due to exposure to extremely low-frequency electromagnetic fields
المؤلفون المشاركون
Habib, Habib A. Nabi
al-Rahim, Muhammad Hamid
al-Mubarak, Ahmad Adil
Freije, Afnan Mahmud
Nusayr, Muhammad A.
Sakhnini, Lama
Kamal, Amir
المصدر
العدد
المجلد 41، العدد 3 (30 سبتمبر/أيلول 2019)، ص ص. 150-154، 5ص.
الناشر
تاريخ النشر
2019-09-30
دولة النشر
البحرين
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: The mechanisms of ELF-EMFs action on the brain are still poorly understood.
One of the possible explanations of these effects could be due to the increase in the intracellular Ca2+.
This increase in Ca2+ may lead to a decrease in cholinergic activity.
These changes in brain activities may lead to changes in motor coordination and motor learning and the possibility that calcium channel blockers might exert neuroprotective effects.
Objective: To evaluate the protective effect of calcium channel blocker (Amlodipine) on deficiency in motor learning abilities of exposed mice to extremely low-frequency electromagnetic Fields ELF-EMFs (1 mT, 50 Hz).
Setting: Animal House, Arabian Gulf University, Kingdom of Bahrain.
Design: An Experimental Animal Study.
Method: Mice were divided randomly into four groups: Group I: (Control group) 8 mice; Group II: 8 mice exposed to ELF-EMF (2 h/day) immediately before each session of training; Group III: 8 mice exposed to ELF-EMF and treated previously by calcium channel blockers (3mg/kg/day) for four weeks; Group IV: 8 mice exposed to ELF-EMF but left to rest for two weeks with no electromagnetic field exposure, then trained.
Rotarod experiments were performed on the four groups.
The effect of rotation speed (45,50,55,60 rpm) was tested on a 5-day course.
Result: Result revealed statistically significant enhancement in the motor coordination performance in Group II, III and IV, over the five days of training, but showed an appreciable deficit in motor learning abilities for Group II.
The results from Group III revealed that learning abilities for exposed mice were improved by giving the mice a therapeutic dose treatment of calcium channel blockers Amlodipine.
These results indicate that the deficiency in motor learning abilities effects is partially due to the increase of the calcium levels in specific parts of mice brains, namely; hippocampus and brainstem, which was supported by an earlier study.
Conclusion: Treating the mice with calcium channel blocker might prevent deficiency in motor learning abilities of exposed mice to ELF-EMF.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sakhnini, Lama& Habib, Habib A. Nabi& Nusayr, Muhammad A.& al-Rahim, Muhammad Hamid& al-Mubarak, Ahmad Adil& Kamal, Amir…[et al.]. 2019. Protective effect of pretreatment with calcium channel blockers on motor coordination deficit of mice due to exposure to extremely low-frequency electromagnetic fields. Bahrain Medical Bulletin،Vol. 41, no. 3, pp.150-154.
https://search.emarefa.net/detail/BIM-896234
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sakhnini, Lama…[et al.]. Protective effect of pretreatment with calcium channel blockers on motor coordination deficit of mice due to exposure to extremely low-frequency electromagnetic fields. Bahrain Medical Bulletin Vol. 41, no. 3 (Sep. 2019), pp.150-154.
https://search.emarefa.net/detail/BIM-896234
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sakhnini, Lama& Habib, Habib A. Nabi& Nusayr, Muhammad A.& al-Rahim, Muhammad Hamid& al-Mubarak, Ahmad Adil& Kamal, Amir…[et al.]. Protective effect of pretreatment with calcium channel blockers on motor coordination deficit of mice due to exposure to extremely low-frequency electromagnetic fields. Bahrain Medical Bulletin. 2019. Vol. 41, no. 3, pp.150-154.
https://search.emarefa.net/detail/BIM-896234
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 153-154
رقم السجل
BIM-896234
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر