The utility of inflammation and platelet biomarkers in patients with acute coronary syndromes
المؤلفون المشاركون
Matowicka Karna, Joanna
Kemona, Halina
Ska, Joanna Kamin
Koper, Olga M.
Czykier, Edyta Siedlecka
Bychowski, Jerzy
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 25، العدد 7 (30 نوفمبر/تشرين الثاني 2018)، ص ص. 1263-1271، 9ص.
الناشر
تاريخ النشر
2018-11-30
دولة النشر
السعودية
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Introduction: Thrombotic and inflammatory mechanisms are involved in the pathophysiology of acute coronary syndrome (ACS).
The aim of the study was the evaluation of inflammation (white blood cells count/WBC, C-reactive protein/CRP, interleukin-6/IL-6) and platelet (platelet count/PLT, mean platelet volume/MPV, large platelet/LPLT, beta-thromboglobulin/b-TG) biomarkers in the groups of ACS patients depending on the severity of signs and symptoms and compared to controls without coronary artery disease.
Materials and methods: The study group included 93 patients categorized into 3 subgroups depending on the severity of signs and symptoms of ACS.
PLT, MPV, LPLT, and WBC were determined on hematological analyzer, IL-6 and b-TG were measured using the ELISA method.
Results: In the whole group of ACS patients WBC, CRP, IL-6, MPV, and b-TG were significantly higher as compared to controls.
Analyzing the inflammation and platelet biomarkers depending on the severity of signs and symptoms in comparison to controls, statistically significant differences for above-mentioned parameters were also found.
There were no significant differences between the advancement of coronary artery changes and inflammation as well as platelet parameters, except for CRP concentrations.
The AUCs for all inflammation parameters tested were similar, however the highest AUCs showed WBC and CRP.
Among platelet parameters the highest AUC revealed b-TG.
Conclusion: Markers of inflammation and platelet activation may be associated to myocardial ischemia and myocardial injury.
WBC, CRP and IL-6 as inflammation parameters and MPV and b-TG as platelet biomarkers may be useful indicators of the presence of coronary artery disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ska, Joanna Kamin& Koper, Olga M.& Czykier, Edyta Siedlecka& Matowicka Karna, Joanna& Bychowski, Jerzy& Kemona, Halina. 2018. The utility of inflammation and platelet biomarkers in patients with acute coronary syndromes. Saudi Journal of Biological Sciences،Vol. 25, no. 7, pp.1263-1271.
https://search.emarefa.net/detail/BIM-896309
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ska, Joanna Kamin…[et al.]. The utility of inflammation and platelet biomarkers in patients with acute coronary syndromes. Saudi Journal of Biological Sciences Vol. 25, no. 7 (Nov. 2018), pp.1263-1271.
https://search.emarefa.net/detail/BIM-896309
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ska, Joanna Kamin& Koper, Olga M.& Czykier, Edyta Siedlecka& Matowicka Karna, Joanna& Bychowski, Jerzy& Kemona, Halina. The utility of inflammation and platelet biomarkers in patients with acute coronary syndromes. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 7, pp.1263-1271.
https://search.emarefa.net/detail/BIM-896309
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1270-1271
رقم السجل
BIM-896309
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر