Blueberry extract attenuates c-radiation-induced hepatocyte damage by modulating oxidative stress and suppressing NF-jB in male rats
المؤلفون المشاركون
al-Khalaf, Maha I.
Khalifah, Faris K.
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 25، العدد 7 (30 نوفمبر/تشرين الثاني 2018)، ص ص. 1272-1277، 6ص.
الناشر
تاريخ النشر
2018-11-30
دولة النشر
السعودية
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Radiation exposure is known to produce many harmful effects in biological systems, and these effects are often mediated by oxygen free radicals.
Because blueberries are rich in antioxidant compounds such as anthocyanins and phenolic acids, we divided forty adult rats into four treatment groups of 10 (G1–4) as follows: G1 rats were used as a control, G2 rats were irradiated with 8 Gy at 2 Gy/week at a dose rate of 0.5 Gy/min, G3 rats were administered blueberry extract (200 mg/kg) and G4 rats were administered blueberry extract during the same irradiation period.
In subsequent determinations, c-irradiated rats had increased levels of cholesterol, triglyceride, high density lipoprotein (HDL) and low density lipoprotein (LDL), and significantly elevated liver enzyme activities, including alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP), and total bilirubin.
In contrast, significant reductions in albumin, total protein and globulin were observed, whereas gamma irradiation decreased activities of the antioxidant enzymes glutathione (GSH), catalase (CAT), xanthine dehydrogenase (XDH) and superoxide dismutase (SOD).
We also observed incremental increases in DNA fragmentation percentages and histopathological changes in liver tissues.
Serum pro-inflammatory cytokine levels (IL-6, IL-10 and TNF-a) were significantly elevated and hepatic NF-rB was upregulated.
In G4 rats, treatments with blueberry extract restored liver pro-oxidant status, reduced cytokine levels, ameliorated histopathological parameters and reduced DNA damage.
In conclusion, c-radiation exerts toxic effects in the rat livers, and blueberry extract is protective against these
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Khalaf, Maha I.& Khalifah, Faris K.. 2018. Blueberry extract attenuates c-radiation-induced hepatocyte damage by modulating oxidative stress and suppressing NF-jB in male rats. Saudi Journal of Biological Sciences،Vol. 25, no. 7, pp.1272-1277.
https://search.emarefa.net/detail/BIM-896312
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Khalaf, Maha I.& Khalifah, Faris K.. Blueberry extract attenuates c-radiation-induced hepatocyte damage by modulating oxidative stress and suppressing NF-jB in male rats. Saudi Journal of Biological Sciences Vol. 25, no. 7 (Nov. 2018), pp.1272-1277.
https://search.emarefa.net/detail/BIM-896312
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Khalaf, Maha I.& Khalifah, Faris K.. Blueberry extract attenuates c-radiation-induced hepatocyte damage by modulating oxidative stress and suppressing NF-jB in male rats. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 7, pp.1272-1277.
https://search.emarefa.net/detail/BIM-896312
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1277
رقم السجل
BIM-896312
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر