Impact of correction of anemia in end-stage renal disease patients on cerebral circulation and cognitive functions
المؤلفون المشاركون
Shakir, Amr Muhammad
Muhammad, Usamah Muhammadi
Muhammad, Mutazz Fathi
al-Khashabah, Sahir Umar
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 29، العدد 6 (31 ديسمبر/كانون الأول 2018)، ص ص. 1333-1341، 9ص.
الناشر
تاريخ النشر
2018-12-31
دولة النشر
السعودية
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
End-stage renal disease (ESRD) patients have been associated with accelerated vascular disease of the cerebral circulation due to uremic toxins.
Furthermore, anemia increases cerebral oxygen extraction fraction which impairs the cerebral vasodilatory capacity.
We evaluated the effect of correction of anemia on cerebral blood flow by measuring the mean blood flow velocity, resistance index (RI), and pulsatility index (PI) in the middle cerebral artery (MCA) in relation to cognitive functions.
We measured the mean blood flow velocity, RI, and PI in MCA of 120 ESRD patients when the hemoglobin (Hb) ranges between 8 and 10 g/dL and after correction of anemia to two Hb ranges between 10-11.5 g/dL and 11.5-12.5 g/dL in the same patients using transcranial Doppler (TCD) ultrasound in relation to cognitive functions assessment by Mini-Mental State Examination.
We observed that there is a mild-to-moderate cognitive impairment in hemodialysis (HD) patients associated with anemia.
With the improvement of anemia, the cognitive functions improved.
There was an improvement of blood flow of MCA with improvement of Hb.
The improvement was obvious at Stage 3 (Hb 11.5-≤12.5 g/dL) in comparison to Stage 2 (Hb 10-<11.5 g/dL) with P <0.001 at all.
The optimal Hb for HD patients ranges from 11.5 to ≤12.5 g/dL which associated with better improvement of cognitive function and cerebral circulation investigated by TCD ultrasound for MCA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shakir, Amr Muhammad& Muhammad, Usamah Muhammadi& Muhammad, Mutazz Fathi& al-Khashabah, Sahir Umar. 2018. Impact of correction of anemia in end-stage renal disease patients on cerebral circulation and cognitive functions. Saudi Journal of Kidney Diseases and Transplantation،Vol. 29, no. 6, pp.1333-1341.
https://search.emarefa.net/detail/BIM-896391
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shakir, Amr Muhammad…[et al.]. Impact of correction of anemia in end-stage renal disease patients on cerebral circulation and cognitive functions. Saudi Journal of Kidney Diseases and Transplantation Vol. 29, no. 6 (Nov. / Dec. 2018), pp.1333-1341.
https://search.emarefa.net/detail/BIM-896391
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shakir, Amr Muhammad& Muhammad, Usamah Muhammadi& Muhammad, Mutazz Fathi& al-Khashabah, Sahir Umar. Impact of correction of anemia in end-stage renal disease patients on cerebral circulation and cognitive functions. Saudi Journal of Kidney Diseases and Transplantation. 2018. Vol. 29, no. 6, pp.1333-1341.
https://search.emarefa.net/detail/BIM-896391
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1341
رقم السجل
BIM-896391
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر