Pediatric focal segmental glomerulosclerosis in Jordan : a tertiary hospital experience

الملخص EN

Our objective is to study the demographical data, clinical course and outcome of children with primary focal segmental glomerulosclerosis (FSGS) in Jordan.

A retrospective chart review of patients with a diagnosis of FSGS at a tertiary care hospital from the period July 2010 to July 2016 was conducted.

A total of 99 patients were analyzed.

The mean age of presentation was 3.71 ± 2.59 years, 66% were male.

At presentation, 66.6% of patients were steroid-resistant, 10% had a steroid dependant course and 20.2% had familial FSGS.

Cyclosporine was used in 66.6% of children with a response rate of 46.9%.

Long-term follow-up showed complete remission in 29.3%, partial remission in 31.3%, end-stage renal disease in 22.2%, and death in 11.1%.

There is a high prevalence of familial FSGS in our Jordanian cohort with a high rate of progression to end-stage kidney disease.