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Heat shock protein 60 as a biomarker for acute kidney injury secondary to septic shock in pediatric patients : Egyptian multicenter experience
المؤلفون المشاركون
al-Gamasy, Muhammad A.
al-Sadiq, Akram E.
Fakhr al-Din, Ahmad R.
al-Buhayri, Iman G.
Kamil, Ashraf F.
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 29، العدد 4 (31 أغسطس/آب 2018)، ص ص. 852-862، 11ص.
الناشر
تاريخ النشر
2018-08-31
دولة النشر
السعودية
عدد الصفحات
11
التخصصات الرئيسية
الموضوعات
الملخص EN
Acute kidney injury (AKI) is an independent predictor of morbidity and mortality for critically ill children at pediatric Intensive Care Units (PICU).
It is proposed that heat shock protein 60 (HSP60) may be either a biomarker or a co-factor of survival in PICU.
The aim of this work is to assess plasma levels of HSP60 in critically ill pediatric patients with AKI secondary to septic shock within the first 24 h of admission.
This study was carried out on 120 pediatric patients admitted to PICUs of four university hospitals.
They were divided into Group 1 included 60 patients meeting the criteria of AKI Network and septic shock, the second group included 60 critically ill patients without AKI or septic shock and the third group was 60 healthy children as controls.
HSP60 levels were measured in the plasma using a commercially available ELISA and difference between groups were analyzed with a Kruskal–Wallis one-way ANOVA.
P <0.05 was considered significant.
There was highly significant increase in plasma levels of HSP60 in Group 1 (median 25.85 ng/mL) compared to both Group 2 (median 6.15 ng/mL) and healthy controls (median 4.35 ng/mL) (P <0.001).
At a cut-off value ≥10 ng/mL, HSP60 sensitivity for prediction of cases with AKI secondary to septic shock was 96.67% with specificity 86.67%, positive predictive value 87.9%, negative predictive value 96.3%, AUC 0.993.
HSP60 levels are significantly elevated in pediatric patients in Group 1 when compared to Groups 2 and 3.
Hence, HSP60 may play a role in the pathogenesis of sepsis in pediatric patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Gamasy, Muhammad A.& al-Sadiq, Akram E.& Fakhr al-Din, Ahmad R.& Kamil, Ashraf F.& al-Buhayri, Iman G.. 2018. Heat shock protein 60 as a biomarker for acute kidney injury secondary to septic shock in pediatric patients : Egyptian multicenter experience. Saudi Journal of Kidney Diseases and Transplantation،Vol. 29, no. 4, pp.852-862.
https://search.emarefa.net/detail/BIM-896542
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Gamasy, Muhammad A.…[et al.]. Heat shock protein 60 as a biomarker for acute kidney injury secondary to septic shock in pediatric patients : Egyptian multicenter experience. Saudi Journal of Kidney Diseases and Transplantation Vol. 29, no. 4 (Jul. / Aug. 2018), pp.852-862.
https://search.emarefa.net/detail/BIM-896542
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Gamasy, Muhammad A.& al-Sadiq, Akram E.& Fakhr al-Din, Ahmad R.& Kamil, Ashraf F.& al-Buhayri, Iman G.. Heat shock protein 60 as a biomarker for acute kidney injury secondary to septic shock in pediatric patients : Egyptian multicenter experience. Saudi Journal of Kidney Diseases and Transplantation. 2018. Vol. 29, no. 4, pp.852-862.
https://search.emarefa.net/detail/BIM-896542
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 862
رقم السجل
BIM-896542
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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