![](/images/graphics-bg.png)
Anti-inflammatory activity of rhein isolated from the flowers of Cassia fistula L. and possible underlying mechanisms
المؤلفون المشاركون
Antonisamy, Paulrayer
Agastian, Paul
Kang, Chang-Won
Kim, Nam-Soo
Kim, Jong Heon
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 26، العدد 1 (31 يناير/كانون الثاني 2019)، ص ص. 96-104، 9ص.
الناشر
تاريخ النشر
2019-01-31
دولة النشر
السعودية
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Objective: Anti-inflammatory activity of rhein in animal models with potential mechanism of actions.
Methods: Rhein was isolated from Cassia fistula L.
flowers collected in Chennai, Tamil Nadu, India.
Its antiinflammatory activity was then investigated in Wistar rats and mice using carrageenan-induced hind paw oedema, croton oil-induced ear oedema, cotton pellet-induced granuloma and acetic acid-induced vascular permeability models.
Results: Administration of rhein (10, 20, 40 mg/kg) significantly (p < 0.05) inhibited carrageenan-induced paw oedema in rats and croton oil-induced ear oedema in mice in dose-dependent manners.
Continual administration of rhein to rats using implanted cotton pellets significantly (p < 0.05) reduced granuloma formation (20 mg/kg: 17.24%; 40 mg/kg: 36.12%) compared to control group animals.
Administration of rhein increased the activities of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) and decreased the levels of nitrite, interleukin-6 (IL-6), interleukin-1b (IL-1b), tumor necrosis factor-a (TNF-a), malondialdehyde (MDA) and vascular endothelial growth factor (VEGF) compared to control animals.
Western blotting results revealed that rhein diminished carrageenan-induced cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) and increased heme oxygenase (HO)-1, nuclear factor erythroid 2–related factor 2 (Nrf2), peroxisome proliferator-activated receptor gamma (PPAR)-c and heat shock protein (HSP)-72 expression after 6 h in the paw oedema model.
Conclusion: The anti-inflammatory mechanisms of rhein might be related to decrease in the levels of MDA, iNOS and COX-2 and the stimulation of HO-1, PPAR-c and Nrf2 expression via increases in the activities of CAT, SOD and GSH-px through the suppression of nitrite, TNF-a, IL-6 and IL-1b.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Antonisamy, Paulrayer& Agastian, Paul& Kang, Chang-Won& Kim, Nam-Soo& Kim, Jong Heon. 2019. Anti-inflammatory activity of rhein isolated from the flowers of Cassia fistula L. and possible underlying mechanisms. Saudi Journal of Biological Sciences،Vol. 26, no. 1, pp.96-104.
https://search.emarefa.net/detail/BIM-896649
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Antonisamy, Paulrayer…[et al.]. Anti-inflammatory activity of rhein isolated from the flowers of Cassia fistula L. and possible underlying mechanisms. Saudi Journal of Biological Sciences Vol. 26, no. 1 (Jan. 2019), pp.96-104.
https://search.emarefa.net/detail/BIM-896649
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Antonisamy, Paulrayer& Agastian, Paul& Kang, Chang-Won& Kim, Nam-Soo& Kim, Jong Heon. Anti-inflammatory activity of rhein isolated from the flowers of Cassia fistula L. and possible underlying mechanisms. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 1, pp.96-104.
https://search.emarefa.net/detail/BIM-896649
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 103-104
رقم السجل
BIM-896649
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)