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Silver nanopaticles synthesized using the seed extract of trigonella foenum-graecum L. and their antimicrobial mechanism and anticancer properties
المؤلفون المشاركون
al-Maliki, Muhammad A.
Varghese, Rakesh
Ilavenil, Soundharrajan
Rebecca, Jeyanthi
Choi, Ki Choon
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 26، العدد 1 (31 يناير/كانون الثاني 2019)، ص ص. 148-154، 7ص.
الناشر
تاريخ النشر
2019-01-31
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
- التخليق الحيوي
- السرطان(مرض)
- الفضة
- العلاج المناعي
- الأدوية المضادة للأورام
- مضادات الجراثيم
- المستخلصات النباتية
- الجسيمات النانوية
- الحلبة(نبات)
الملخص EN
Background: Synthesis of silver nanoparticles (AgNPs) through biological route plays an important role in their applications in the medical field, especially in the prevention of disease causing microbial pathogens and arresting the propagation of cancer cells.
The stable, green synthesis of AgNPs is very much welcomed in the medical field because of their low toxicity.
Therefore, the demands of AgNPs synthesised biologically is on the rise.
The present study aimed to investigate the antimicrobial mechanisms and anticancer properties of the AgNPs synthesized using the seed extract of Trigonella foenum-graecum L.
The AgNPs were characterized by UV–vis, SEM, XRD, FTIR and EDAX analysis.
The minimum inhibitory concentrations (MIC) of the AgNPs were determined by the broth micro dilution method.
Results: The formation of brownish red color indicated the formation NPs with the absorption maximum at 420 nm.
The average size was found to be 33.93 nm and sphere shaped.
The FTIR spectrum revealed the absorption bands at 3340 cm1 and 1635 cm1 indicated the presence of AOH or ACOOH and amide group stretching in the AgNPs.
The X-ray diffraction report confirmed the presence of strong peak values of 2h within the angle of 37.1.
The lowest MIC of the AgNPs against Staphylococcus aureus was 62.5 lg mL1 .
MIC values against Escherichia coli and Klebsiella pneumonia, were 125 and 250 lg mL1 respectively.
The MIC of the AgNPs against Aspergillus flavus, Trichophyton rubrum and Trichoderma viridiae were each 250 lg mL1 , respectively.
The extracellular protein concentration, levels of lactate dehydrogenase and alkaline phosphtase enzyme in the AgNPs treated bacterial pathogens demonstrated greater antimicrobial mechanism.
Additionally, the AgNPs exhibited significant anticancer activity against the MCF7 and Vero cell lines.
Conclus
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Varghese, Rakesh& al-Maliki, Muhammad A.& Ilavenil, Soundharrajan& Rebecca, Jeyanthi& Choi, Ki Choon. 2019. Silver nanopaticles synthesized using the seed extract of trigonella foenum-graecum L. and their antimicrobial mechanism and anticancer properties. Saudi Journal of Biological Sciences،Vol. 26, no. 1, pp.148-154.
https://search.emarefa.net/detail/BIM-896729
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Varghese, Rakesh…[et al.]. Silver nanopaticles synthesized using the seed extract of trigonella foenum-graecum L. and their antimicrobial mechanism and anticancer properties. Saudi Journal of Biological Sciences Vol. 26, no. 1 (Jan. 2019), pp.148-154.
https://search.emarefa.net/detail/BIM-896729
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Varghese, Rakesh& al-Maliki, Muhammad A.& Ilavenil, Soundharrajan& Rebecca, Jeyanthi& Choi, Ki Choon. Silver nanopaticles synthesized using the seed extract of trigonella foenum-graecum L. and their antimicrobial mechanism and anticancer properties. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 1, pp.148-154.
https://search.emarefa.net/detail/BIM-896729
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 154
رقم السجل
BIM-896729
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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