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Interfering PLD1-PED PEA15 interaction using self-inhibitory peptides : an in silico study to discover novel therapeutic candidates against type 2 diabetes
المؤلفون المشاركون
Yadav, Brijesh S.
Baig, Muhammad Hasan
Kausar, Muhammad Adnan
Husayn, Fahd Mabud
Shakil, Shazi
Said, Muhammad
Ahmad, Irfan
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 26، العدد 1 (31 يناير/كانون الثاني 2019)، ص ص. 160-164، 5ص.
الناشر
تاريخ النشر
2019-01-31
دولة النشر
السعودية
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Diabetes type 2 (T2D) is a very complex disorder with a large number of cases reported worldwide.
There are several reported molecular targets which are being used towards drug design.
In spite of extensive research efforts, there is no sure shot treatment available.
One of the major reasons for this failure or restricted success in T2D research is the identification of a major/breakthrough therapeutic target responsible for the progression of T2D.
It has been well documented that one of the major causes mediating the insulin resistance is the interaction of PLD1 with PED/PEA15.
Herein, we have performed in silico experiments to investigate the interaction between PLD1 with PED/PEA15.
Furthermore, this study has explored pertinent molecular interactions involving the self-derived peptides.
The peptides identified in this study are found to be capable of restricting the interaction of these two proteins.
Accordingly, the study suggests that the ‘‘self-derived peptides” could be used as promising therapeutic candidate(s) against T2D.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Baig, Muhammad Hasan& Kausar, Muhammad Adnan& Husayn, Fahd Mabud& Shakil, Shazi& Ahmad, Irfan& Yadav, Brijesh S.…[et al.]. 2019. Interfering PLD1-PED PEA15 interaction using self-inhibitory peptides : an in silico study to discover novel therapeutic candidates against type 2 diabetes. Saudi Journal of Biological Sciences،Vol. 26, no. 1, pp.160-164.
https://search.emarefa.net/detail/BIM-896737
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Baig, Muhammad Hasan…[et al.]. Interfering PLD1-PED PEA15 interaction using self-inhibitory peptides : an in silico study to discover novel therapeutic candidates against type 2 diabetes. Saudi Journal of Biological Sciences Vol. 26, no. 1 (Jan. 2019), pp.160-164.
https://search.emarefa.net/detail/BIM-896737
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Baig, Muhammad Hasan& Kausar, Muhammad Adnan& Husayn, Fahd Mabud& Shakil, Shazi& Ahmad, Irfan& Yadav, Brijesh S.…[et al.]. Interfering PLD1-PED PEA15 interaction using self-inhibitory peptides : an in silico study to discover novel therapeutic candidates against type 2 diabetes. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 1, pp.160-164.
https://search.emarefa.net/detail/BIM-896737
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p.164
رقم السجل
BIM-896737
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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