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ZAP-70 expression in B-Chronic lymphocytic leukemia in sudanese patients
المؤلفون المشاركون
Mirghani, Tariq Hakim
Abd al-Qadir, Inam Abd al-Rahman
al-Tayyib, Nada Hasan
al-Tahir, Tasnim Ahmad
al-Tayyib, Usamah Ali
Fadl, Iman Abbas
Abd al-Rahman, al-Dardiri M.
المصدر
Sudan Journal of Medical Sciences
العدد
المجلد 13، العدد 4 (31 ديسمبر/كانون الأول 2018)، ص ص. 230-239، 10ص.
الناشر
جامعة أم درمان الإسلامية كلية الطب
تاريخ النشر
2018-12-31
دولة النشر
السودان
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background: Chronic lymphocytic leukemia is the most common form of leukemia in adults.
The prognostic impact of ZAP-70 in CLL has been reported in several studies.
The aim of conducting this study was to investigate the prevalence of ZAP-70 in Sudanese patients with chronic lymphocytic leukemia attending Khartoum Oncology Hospital.
Materials and Methods: A total of 93 newly diagnosed patients with chronic lymphocytic leukemia were enrolled in this study.
Lymphadenopathy and organomegaly were assessed in all participants using clinical examination, chest radiography, and abdominal ultrasound.
Full blood count was carried out by an automated hematology analyzer.
ZAP-70 was evaluated using flowcytometry on peripheral blood samples.
ZAP-70 was defined as positive expression at a cutoff level of 20%.
Results: There were 63 (67.7%) males and 30 (32.3%) females and the median age of the group was 63 years; 68 patients (73.1%) were presented with anemia and 66 (70.9%) had lymphadenopath;y.
Majority of our patients 35 (37.6%) were in Rai stage IV.
ZAP-70 positivity was detected in 21 patients (22.6%).
There was no statistically significant association of ZAP-70 with age, sex, lymphadenopathy, organomegaly, hemoglobin concentration, total white blood cell count, platelet count and Rai staging system (p-value 0.05).
Conclusion: Only 21 patients (22.6%) were ZAP-70 positive.
There was no association between ZAP-70 and the study variables.
Further studies to evaluate prognostic role of ZAP-70 in Sudanese patients with chronic lymphocytic leukemia are recommended.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Qadir, Inam Abd al-Rahman& al-Tayyib, Nada Hasan& al-Tahir, Tasnim Ahmad& al-Tayyib, Usamah Ali& Fadl, Iman Abbas& Abd al-Rahman, al-Dardiri M.…[et al.]. 2018. ZAP-70 expression in B-Chronic lymphocytic leukemia in sudanese patients. Sudan Journal of Medical Sciences،Vol. 13, no. 4, pp.230-239.
https://search.emarefa.net/detail/BIM-897207
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Qadir, Inam Abd al-Rahman…[et al.]. ZAP-70 expression in B-Chronic lymphocytic leukemia in sudanese patients. Sudan Journal of Medical Sciences Vol. 13, no. 4 (2018), pp.230-239.
https://search.emarefa.net/detail/BIM-897207
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Qadir, Inam Abd al-Rahman& al-Tayyib, Nada Hasan& al-Tahir, Tasnim Ahmad& al-Tayyib, Usamah Ali& Fadl, Iman Abbas& Abd al-Rahman, al-Dardiri M.…[et al.]. ZAP-70 expression in B-Chronic lymphocytic leukemia in sudanese patients. Sudan Journal of Medical Sciences. 2018. Vol. 13, no. 4, pp.230-239.
https://search.emarefa.net/detail/BIM-897207
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 237-239
رقم السجل
BIM-897207
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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