Impact of bicalutamide : an anti-androgen on rat testis

الملخص EN

Bicalutamide/Casodex is a non-steroidal anti-androgen drug which used in treatment of prostate cancer.

Castration by using anti-androgens such as bicalutamide became a successful strategy for prostate cancer metastasis suppression.

The goals of the present work were to study the body weight, biochemical, histological and immunohistochemical changes induced by daily administration of bicalutamide 0.8mg/Kg body weight of rats.

Treatment with bicalutamide caused non-significant decrease in relative testis weight, disturbing the histological architecture of the testis, decrease of sperm count, germinal layer depletion, increasing the apoptotic index of germinal layer cells and a decrease in testosterone level compared to control.

In conclusion, bicalutamide treatment induced various biochemical, histological and immunological changes in rat testis.