The role of hypogammaglobulinemia in childhood asthma
المؤلفون المشاركون
Bahceciler, Nerin Nadir
Yuruker, Ozel
Sanlidag, Burcin
Uncu, Murat
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 20، العدد 9 (30 سبتمبر/أيلول 2018)، ص ص. 1-9، 9ص.
الناشر
تاريخ النشر
2018-09-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background: The relationship between hypogammaglobulinemia and wheezing in childhood has been previously revealed.
Objectives: The study aimed to investigate co-morbid immune deficiency in unresponsive asthmatic children, characterize the type of immune deficiency, and determine any possible effect of immune deficiency treatment on the applied standard guideline of asthma treatment.
Methods: This was a prospective study conducted between January 2012 and December 2014.
A total of 286 children whose serum immunoglobulin (Ig) levels had been analyzed were collected.
Among those children, 125 (m/f = 79:46, mean +-SD of age = 41.3 + 25.2 months) were enrolled as they had uncontrolled moderate to persistent asthma.
Those 125 children were categorized as the only asthma group and the asthma + hypogammaglobulinemia (HGG) group depending on their immunoglobulin concentrations.
Results: Seventy-six of the 125 children (60.8%) had co-morbid hypogammaglobulinemia.
Atopy was higher in the Asthma + HGG group (P = 0.044).
The most frequent co-morbid HGG was transient hypogammaglobulinemia of infancy (THGI) (46.1%) and IgG subclass deficiency (32.9%).
Although the comparison of the percentage use of the inhaled corticosteroids (ICSs) showed no significant difference between the two groups at the initial evaluation, the dose of ICS significantly decreased only in the asthma + HGG group (P = 0.017).
Conclusions: The majority of asthmatic children having symptoms despite appropriate guideline-based treatment may have a co-morbid immunological abnormality.
Presented data demonstrated the necessity of immunological evaluation of uncontrolled asthmatic children to prevent long-term side effects of high-dose ICS, reduce the frequency and severity of asthma symptoms, and improve the quality of life.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yuruker, Ozel& Sanlidag, Burcin& Uncu, Murat& Bahceciler, Nerin Nadir. 2018. The role of hypogammaglobulinemia in childhood asthma. Iranian Red Crescent Medical Journal،Vol. 20, no. 9, pp.1-9.
https://search.emarefa.net/detail/BIM-897353
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yuruker, Ozel…[et al.]. The role of hypogammaglobulinemia in childhood asthma. Iranian Red Crescent Medical Journal Vol. 20, no. 9 (Sep. 2018), pp.1-9.
https://search.emarefa.net/detail/BIM-897353
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yuruker, Ozel& Sanlidag, Burcin& Uncu, Murat& Bahceciler, Nerin Nadir. The role of hypogammaglobulinemia in childhood asthma. Iranian Red Crescent Medical Journal. 2018. Vol. 20, no. 9, pp.1-9.
https://search.emarefa.net/detail/BIM-897353
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 9
رقم السجل
BIM-897353
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر