Effect of strontium ranelate on multiple organ damage in a rat sepsis model
المؤلفون المشاركون
Soylu, Sinan
Inan, Zaynab Deniz Sahin
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 20، العدد 9 (30 سبتمبر/أيلول 2018)، ص ص. 1-7، 7ص.
الناشر
تاريخ النشر
2018-09-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background: Sepsis and multiple organ dysfunction syndrome (MODS) are life-threatening conditions common in intensive care units.
In this regard, studies have shown that Strontium ranelate has anti-inflammatory activity by blocking tumor necrosis factor-alpha (TNFα).
Objectives: This study aimed to investigate the effect of Strontium ranelate on MODS in an experimental sepsis model Methods: The study protocol was approved by Cumhuriyet University Institutional Ethics Committee for Animal Experiments (Sivas-Turkiye, date 07/12/2017).
Twenty female Wistar-Albino rats were randomly divided into four groups of sham operation, cecal ligation and perforation (CLP), CLP + Strontium (S) (oral 40 mg/kg for 7 days), and S (40 mg/kg oral preoperative 5 days) + CLP + S (oral 40 mg/kg for 7 days).
Blood samples were taken, and alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), and creatinine were studied.
Tissues were removed, and inflammation scores were determined.
Results: The mean inflammation scores of lung, liver, and renal tissues were found to be the lowest in the sham group (0.8 ± 0.45), and they increased in the S + CLP + S (1.6 ± 0.55) and CLP + S (3.4 ± 0.55) groups, respectively, with the highest score in the CLP (3.8 ± 0.45) group.
It was found that there was no statistical difference between the sham and S + CLP + S groups (P > 0.05); however, there was a significant difference between the other groups (P < 0.05).
The mean ALT, AST, BUN and creatinine values were found to be the lowest in the sham group, and they increased in the S + CLP + S and CLP + S groups, respectively, with the highest score in the CLP group.
Regarding the mean ALT results, it was noted that there was no significant difference between the sham and S + CLP + S groups (P > 0.05); however, there was a significant difference between the other groups in terms of mean ALT, and there was a significant difference between all the groups in terms of mean AST, BUN, and creatinine (P < 0.05).
Conclusions: It was concluded that Strontium ranelate reduced the development of life-threatening MODS in patients with sepsis, especially when it was administered before the development of sepsis, by suppressing inflammatory mediators.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Soylu, Sinan& Inan, Zaynab Deniz Sahin. 2018. Effect of strontium ranelate on multiple organ damage in a rat sepsis model. Iranian Red Crescent Medical Journal،Vol. 20, no. 9, pp.1-7.
https://search.emarefa.net/detail/BIM-897358
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Soylu, Sinan& Inan, Zaynab Deniz Sahin. Effect of strontium ranelate on multiple organ damage in a rat sepsis model. Iranian Red Crescent Medical Journal Vol. 20, no. 9 (Sep. 2018), pp.1-7.
https://search.emarefa.net/detail/BIM-897358
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Soylu, Sinan& Inan, Zaynab Deniz Sahin. Effect of strontium ranelate on multiple organ damage in a rat sepsis model. Iranian Red Crescent Medical Journal. 2018. Vol. 20, no. 9, pp.1-7.
https://search.emarefa.net/detail/BIM-897358
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 6-7
رقم السجل
BIM-897358
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر