Clinical significance of abnormal results of second trimester hormones in the absence of aneuploidy

المؤلفون المشاركون

Sutcu, Havva
Uzun, Isil
Sayın, N Cenk
Inan, Cihan
Erzincan, Selen
Varol, Fusun

المصدر

Iranian Red Crescent Medical Journal

العدد

المجلد 20، العدد 4 (30 إبريل/نيسان 2018)، ص ص. 1-5، 5ص.

الناشر

المستشفى الإيراني

تاريخ النشر

2018-04-30

دولة النشر

الإمارات العربية المتحدة

عدد الصفحات

5

التخصصات الرئيسية

الطب البشري

الملخص EN

Background : Abnormal levels of hormones during the second trimester of pregnancy may predict genetic disorders and complications of pregnancy.

Objectives : This study was performed to evaluate the clinical significance of abnormal results in second-trimester markers in the absence of aneuploidy.

Methods : This case-control study was conducted between May 2014 and December 2015 in the maternal-fetal unit, Trakya University Faculty of Medicine in Turkey.

Overall, 108 Turkish pregnant females were included in this study.

This research recruited patients (n = 46) with normal karyotype, who underwent invasive prenatal tests because of abnormal levels of second-trimester hormones, along with a cohort of controls (n = 31) with hormonal results within normal ranges.

For each patient, the researchers recorded the mode of delivery, gestational age at delivery, birth weight, complications, and adverse outcome of the pregnancy.

Data were analyzed using Fisher’s exact tests and Yates continuity correction tests for qualitative variables, and t- test and Mann-Whitney U test for quantitative variables.

Results: Maternal age (meanSD) of the entire group was 31.775.68 years (study group: 31.234.39; controls: 32.136.43, P > 0.05).

Preterm delivery and preeclampsia were significantly higher in the study group (P = 0.02).

In the study group, Alpha Fetoprotein (AFP) levels were significantly higher in patients with preeclampsia yet not in the controls.

The AFP values under 0.77 multiple of the median in patients with elevated test results in the absence of aneuploidy appeared to be associated with the development of preeclampsia later in pregnancy.

Conclusions : Although the significance of higher AFP values have been discussed in the literature in terms of the development of adverse outcomes, the present study suggests that lower values must also be taken into account during patient follow-up.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Uzun, Isil& Sayın, N Cenk& Inan, Cihan& Erzincan, Selen& Sutcu, Havva& Varol, Fusun. 2018. Clinical significance of abnormal results of second trimester hormones in the absence of aneuploidy. Iranian Red Crescent Medical Journal،Vol. 20, no. 4, pp.1-5.
https://search.emarefa.net/detail/BIM-897764

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Uzun, Isil…[et al.]. Clinical significance of abnormal results of second trimester hormones in the absence of aneuploidy. Iranian Red Crescent Medical Journal Vol. 20, no. 4 (Apr. 2018), pp.1-5.
https://search.emarefa.net/detail/BIM-897764

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Uzun, Isil& Sayın, N Cenk& Inan, Cihan& Erzincan, Selen& Sutcu, Havva& Varol, Fusun. Clinical significance of abnormal results of second trimester hormones in the absence of aneuploidy. Iranian Red Crescent Medical Journal. 2018. Vol. 20, no. 4, pp.1-5.
https://search.emarefa.net/detail/BIM-897764

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 5

رقم السجل

BIM-897764