Sophocarpine attenuates chronic constriction sciatic nerve injury-induced neuropathic pain in mice by inhibiting the HMGB1 TLR4 NF-κB signaling pathway
المؤلفون المشاركون
Jin, Shaoju
Xu, Songtao
Guo, Kunpeng
Guo, Liucheng
Zhou, Junjun
Wang, Tingting
Wang, Rong
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 21، العدد 9 (30 سبتمبر/أيلول 2019)، ص ص. 1-9، 9ص.
الناشر
تاريخ النشر
2019-09-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Sophocarpine (SC) is a major alkaloid extracted from Sophora alopecuroides L.
Our previous study showed that SC has analgesic effects on neuropathic pain induced by chronic constriction injury (CCI).
However, the exact analgesic mechanism of SC on neuropathic pain has not yet been elucidated.
Objectives: The current study aimed to examine the anti-neuropathic pain effects of SC on the HMGB1/TLR4/NF-κB signaling pathway to explore its analgesic mechanism in neuropathic pain.
Methods: In this experimental study, the neuropathic pain mouse model was established by CCI of the sciatic nerve in a universityaffiliated animal lab, China, 2016.
Mechanical withdrawal threshold (MWT), thermal withdrawal latency (TWL), cold withdrawal threshold (CWT), and tail-curling latency (TCL) were used to assess the antinociceptive effect of SC in neuropathic pain mice.
The mRNA and protein expression levels of HMGB1, TLR4, NF-κB, p-NF-κB, TNF-α, and IL-6 in the spinal cord of neuropathic pain mice were detected by reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting.
Results: Treatment with 40 and 20 mg/kg of SC was effective in increasing MWT, lengthening TWL, reducing CWT, and prolonging TCL in mice with neuropathic pain induced by CCI.
Compared to the neuropathic-pain model group, treatment with 40 mg/kg of SC could effectively down-regulate HMGB1, TLR4, NF-κB, p-NF-κB, TNF-α, and IL-6 mRNA and protein expression levels in the spinal cord of mice with neuropathic pain induced by CCI.
Conclusions: Our results showed that SC has analgesic effects on neuropathic pain induced by CCI, and its analgesic mechanism may be related to down-regulating the HMGB1/TLR4/NF-κB signaling pathway
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jin, Shaoju& Xu, Songtao& Wang, Rong& Wang, Tingting& Guo, Kunpeng& Guo, Liucheng…[et al.]. 2019. Sophocarpine attenuates chronic constriction sciatic nerve injury-induced neuropathic pain in mice by inhibiting the HMGB1 TLR4 NF-κB signaling pathway. Iranian Red Crescent Medical Journal،Vol. 21, no. 9, pp.1-9.
https://search.emarefa.net/detail/BIM-898340
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jin, Shaoju…[et al.]. Sophocarpine attenuates chronic constriction sciatic nerve injury-induced neuropathic pain in mice by inhibiting the HMGB1 TLR4 NF-κB signaling pathway. Iranian Red Crescent Medical Journal Vol. 21, no. 9 (Sep. 2019), pp.1-9.
https://search.emarefa.net/detail/BIM-898340
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jin, Shaoju& Xu, Songtao& Wang, Rong& Wang, Tingting& Guo, Kunpeng& Guo, Liucheng…[et al.]. Sophocarpine attenuates chronic constriction sciatic nerve injury-induced neuropathic pain in mice by inhibiting the HMGB1 TLR4 NF-κB signaling pathway. Iranian Red Crescent Medical Journal. 2019. Vol. 21, no. 9, pp.1-9.
https://search.emarefa.net/detail/BIM-898340
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 8-9
رقم السجل
BIM-898340
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر