Serum matrix metalloproteinase-9 level in systemic lupus erythematosus with peripheral neuropathy
المؤلفون المشاركون
Ibrahim, Nifin Abd Allah
al-Hadidi, Abir Shawqi
Hasan, Marwah Muhammad
Imam, Muhammad Hasan
Kuraym, Hamdi Khamis
المصدر
Egyptian Rheumatology and Rehabilitation
العدد
المجلد 46، العدد 4 (31 ديسمبر/كانون الأول 2019)، ص ص. 211-220، 10ص.
الناشر
الجمعية المصرية للروماتيزم و التأهيل
تاريخ النشر
2019-12-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
Objective To evaluate whether serum matrix metalloproteinase-9 (MMP-9) is associated with peripheral neuropathy (PN) in patients with systemic lupus erythematosus (SLE) and to determine the relationship between MMP-9 serum level and SLE disease activity, lupus manifestations, and laboratory markers.
Patients and methods A total of 30 patients with SLE with PN, 30 patients with SLE without PN, and 20 healthy controls were included in this study.
SLE clinical manifestations, Systemic Lupus Activity Measure (SLAM) index, and laboratory markers were evaluated.
All the data were compared and correlated with serum MMP-9 level.
Results MMP-9 showed a significant increase in frequency in SLE with PN group compared with SLE without PN group (P1=0.037), SLE with PN group compared with control group (P2<0.001), and SLE without PN group compared with control group (P3<0.001).
In comparison between SLE with normal MMP-9 group versus SLE with high MMP-9 group, it showed no statistically significant difference between the two groups regarding demographic data, SLAM index, Erythrocytes sedimentation rate (ESR), C-reactive protein (CRP), Antinuclear antibodies (ANA), Antiphospholipid antibodies (APL), C3, C4, anti-double-stranded DNA, and lupus clinical features, except malar rash and lupus nephritis, which showed significant increase in SLE with high MMP-9 group compared with SLE with normal MMP-9 group (P=0.042 for each).
A significant positive correlation was detected between MMP-9 serum level and SLAM index (P=0.037), whereas antidouble- stranded DNA did not show significant correlation.
There was a significant relation between increasing the risk of PN and MMP-9 (odds ratio=4.031).
Conclusion Significant elevation of serum MMP-9 may increase the risk of PN in patients with SLE, and it may correlate with disease activity, lupus nephritis, and skin involvement.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Imam, Muhammad Hasan& Kuraym, Hamdi Khamis& Hasan, Marwah Muhammad& al-Hadidi, Abir Shawqi& Ibrahim, Nifin Abd Allah. 2019. Serum matrix metalloproteinase-9 level in systemic lupus erythematosus with peripheral neuropathy. Egyptian Rheumatology and Rehabilitation،Vol. 46, no. 4, pp.211-220.
https://search.emarefa.net/detail/BIM-899674
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Imam, Muhammad Hasan…[et al.]. Serum matrix metalloproteinase-9 level in systemic lupus erythematosus with peripheral neuropathy. Egyptian Rheumatology and Rehabilitation Vol. 46, no. 4 (Oct. / Dec. 2019), pp.211-220.
https://search.emarefa.net/detail/BIM-899674
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Imam, Muhammad Hasan& Kuraym, Hamdi Khamis& Hasan, Marwah Muhammad& al-Hadidi, Abir Shawqi& Ibrahim, Nifin Abd Allah. Serum matrix metalloproteinase-9 level in systemic lupus erythematosus with peripheral neuropathy. Egyptian Rheumatology and Rehabilitation. 2019. Vol. 46, no. 4, pp.211-220.
https://search.emarefa.net/detail/BIM-899674
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 220
رقم السجل
BIM-899674
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر