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Outcome of Omani women with breast cancer-associated brain metastases experience from a University Hospital
المؤلفون المشاركون
Kumar, Shayam
Zahid, Khawajah Farhan
al-Bimani, Khalid
Tanwir, Ahmad
Burney, Ikram A.
al-Mundhiri, Mansur
al-Ajmi, Adil
المصدر
العدد
المجلد 34، العدد 5 (30 سبتمبر/أيلول 2019)، ص ص. 412-419، 8ص.
الناشر
المجلس العماني للاختصاصات الطبية
تاريخ النشر
2019-09-30
دولة النشر
سلطنة عمان
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Objectives: Breast cancer (BC) is the leading cancer among women.
Almost 20% of patients develop brain metastases (BM) and die shortly afterward.
There is a dearth of data on the survival outcome of BC patients with BM from the Arab world.
Methods: Consecutive women diagnosed with BC who developed radiologicallyconfirmed BM during their illness were identified through the hospital’s electronic patient’s records.
Clinicopathological features and treatment outcomes were recorded.
Survival was calculated using the Kaplan-Meier method, and factors affecting survival were studied using log-rank analysis.
Results: Between January 2003 and June 2015, a total of 692 patients were treated for BC at our institute.
Forty-eight (6.9%) developed BM.
The median age at the diagnosis of BM was 45.2 years.
More than half of cohort (54.2%) had HER2 positive disease, while 27.1% had the triple-negative disease.
The median time interval between the diagnosis of BC and the development of BM was 21 months, and median survival after development of brain disease was seven months.
On univariate analysis, pathological grade, previous systemic treatment, brain as the first site of metastases, brain as the only site of metastases, treatment of BM, systemic treatment after BM, and diagnosis-specific graded prognostic assessment (DS-GPA) score significantly affected survival.
On multivariate Cox regression analysis, the brain as the first site of metastases, treatment for brain disease, treatment type, and DS-GPA score significantly affected survival post-BM.
Conclusions: Our data indicate that Omani women are diagnosed with BC at a younger age, develop BM earlier, and carry a poor outcome
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zahid, Khawajah Farhan& Kumar, Shayam& al-Bimani, Khalid& Tanwir, Ahmad& al-Ajmi, Adil& Burney, Ikram A.…[et al.]. 2019. Outcome of Omani women with breast cancer-associated brain metastases experience from a University Hospital. Oman Medical Journal،Vol. 34, no. 5, pp.412-419.
https://search.emarefa.net/detail/BIM-899944
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zahid, Khawajah Farhan…[et al.]. Outcome of Omani women with breast cancer-associated brain metastases experience from a University Hospital. Oman Medical Journal Vol. 34, no. 5 (Sep. 2019), pp.412-419.
https://search.emarefa.net/detail/BIM-899944
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zahid, Khawajah Farhan& Kumar, Shayam& al-Bimani, Khalid& Tanwir, Ahmad& al-Ajmi, Adil& Burney, Ikram A.…[et al.]. Outcome of Omani women with breast cancer-associated brain metastases experience from a University Hospital. Oman Medical Journal. 2019. Vol. 34, no. 5, pp.412-419.
https://search.emarefa.net/detail/BIM-899944
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 418-419
رقم السجل
BIM-899944
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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