Role of leukemia inhibitory factor (LIF) gene variation on implantation rate following IVF program in PCOS and non PCOS women
المؤلفون المشاركون
Husayn, Zaynah F.
al-Musawi, Bushra J.
al-Dujaili, Sad S.
Aziz, Ismail Husayn
المصدر
Iraqi Journal of Biotechnology
العدد
المجلد 17، العدد 2 (30 سبتمبر/أيلول 2018)، ص ص. 57-67، 11ص.
الناشر
جامعة بغداد معهد الهندسة الوراثية و التقنيات الإحيائية للدراسات العليا
تاريخ النشر
2018-09-30
دولة النشر
العراق
عدد الصفحات
11
التخصصات الرئيسية
الموضوعات
الملخص EN
Implantation of the blastocysts into the maternal uterus is a crucial step in mammalian reproduction, which is controlled by a number of complex molecules like hormones, cytokines, and growth factors and their cross talk.
A network of these molecules plays a crucial role in preparing receptive endometrial and blastocysts.
This study aimed to found out the role of Leukemia inhibitory factor (LIF) , gene expression, concentration and genetic polymorphisms in the endometrial that may interfere with implantation process of polycystic ovary syndrome(PCOS) and non-PCOS women.
A convenient blood (6ml)sample of 80 infertile women undergoing in vitro fertilization (IVF) program were intentionally divided according to the cause of infertility into 40 healthy women their husbands complaining from male infertility factors, and 40 infertile women with polycystic ovary syndrome.
Leukemia inhibitory factor( LIFs) were measured on ovulatory and luteal phase of cycle (CD14- CD16,17) at the day of ovarian pickup and embryo transfer by using quantitive polymerase chain reaction(qPCR ), Elisa technique ,polymerase chain reaction(PCR) and sequencing to determine any genetics polymorphisms in LIFgene study.
Results of the present study indicate that no mutation was detected in LIF gene in the healthy and PCOS women.
The LIF gene expression in addition to levels of serum leukemia inhibitory factors are more valuable in predicting the pregnancy out come in infertile PCOS women than in non-PCOS women .This result can be utilized to be used as predictors of implantation window for successful implantation and pregnancy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Husayn, Zaynah F.& al-Musawi, Bushra J.& Aziz, Ismail Husayn& al-Dujaili, Sad S.. 2018. Role of leukemia inhibitory factor (LIF) gene variation on implantation rate following IVF program in PCOS and non PCOS women. Iraqi Journal of Biotechnology،Vol. 17, no. 2, pp.57-67.
https://search.emarefa.net/detail/BIM-900324
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Aziz, Ismail Husayn…[et al.]. Role of leukemia inhibitory factor (LIF) gene variation on implantation rate following IVF program in PCOS and non PCOS women. Iraqi Journal of Biotechnology Vol. 17, no. 2 (Sep. 2018), pp.57-67.
https://search.emarefa.net/detail/BIM-900324
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Husayn, Zaynah F.& al-Musawi, Bushra J.& Aziz, Ismail Husayn& al-Dujaili, Sad S.. Role of leukemia inhibitory factor (LIF) gene variation on implantation rate following IVF program in PCOS and non PCOS women. Iraqi Journal of Biotechnology. 2018. Vol. 17, no. 2, pp.57-67.
https://search.emarefa.net/detail/BIM-900324
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 65-67
رقم السجل
BIM-900324
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر