![](/images/graphics-bg.png)
Biological activities of ginger against cadmium-induced renal toxicity
المؤلفون المشاركون
Jabr, Sami A.
al-Ghadir, Ahmad H.
Ghunaym, Jihan A.
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 26، العدد 2 (28 فبراير/شباط 2019)، ص ص. 382-389، 8ص.
الناشر
تاريخ النشر
2019-02-28
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Our aim was to evaluate the protective and antioxidant effects of ginger extract against cadmiuminduced renal toxicity in animal models and to support the use of ginger as anti-renal failure natural remedy.
Seventy rats were examined in a 4-week experiment to evaluate the effect of Ginger (Zingiber officinale) at doses of 100 and 200 mg/kg body weight on molecular DNA content, antioxidant status, and renal function in rats intoxicated with cadmium at dose of (5 mg/kg) using biochemical and histological analysis.
Renal dysfunction, kidney tissue damage, and oxidative effect were evident in cadmium intoxicated rats as estimated by significant increase in (creatinine, urea), decrease in (creatinine clearance and reabsorption rate of urine albumin), increase in MDA, decrease in total antioxidant status (TAC), reduction in DNA content, and histopathological changes of kidneys’ tissues compared to control rats.
Treatment with ginger resulted in significant restoring of renal function biomarkers, TAC, molecular DNA, and histological improvements which occurs via free radical scavenging and regenerative mechanisms.
The activity of ginger was supported by estimation of bioactive phenolic and falvinods constituents.
Twenty-eight polyphenolic compounds were estimated in ginger extract; [6]-gingerol, [6]- shogaol, citral and pyrogallol were the highest amounts in ginger, and supposed to be responsible for its major antioxidant and free radical scavenging activity as shown by In vitro DPPH/b-carotene-linolic acid assay tests.
Consequently, ginger extracts could have a potent protective effects against nephrotoxicity induced by various toxicants.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jabr, Sami A.& al-Ghadir, Ahmad H.& Ghunaym, Jihan A.. 2019. Biological activities of ginger against cadmium-induced renal toxicity. Saudi Journal of Biological Sciences،Vol. 26, no. 2, pp.382-389.
https://search.emarefa.net/detail/BIM-901426
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jabr, Sami A.…[et al.]. Biological activities of ginger against cadmium-induced renal toxicity. Saudi Journal of Biological Sciences Vol. 26, no. 2 (Feb. 2019), pp.382-389.
https://search.emarefa.net/detail/BIM-901426
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jabr, Sami A.& al-Ghadir, Ahmad H.& Ghunaym, Jihan A.. Biological activities of ginger against cadmium-induced renal toxicity. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 2, pp.382-389.
https://search.emarefa.net/detail/BIM-901426
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 114-116
رقم السجل
BIM-901426
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)