Bcl-2 over-expression in urothelial tumors of the bladder : an immunohistochemical study

الملخص EN

Objectives: The aim was, to evaluate the frequency of Bcl-2 over-expression in urothelial tumors of the bladder in Mosul city, to correlate the over-expression with age and sex of the patients, and grade and stage of the tumors, and to compare the results with those of others.

Methods: A retrospective case-series study was performed on 50 urinary bladder urothelial tumors.

The samples were collected from Al-Jamhuri Teaching Hospital in Mosul city, during a period of 8 months from November 2012 through June 2013.

Results: The patients' age was in the range of 23-91 years with a mean of 62.64 year, male:female ratio (9:1).

Approximately half of them were in the seventh decade (42%).

Bcl-2 immunoreactivity was observed in 42% of the cases, it was positive in 4/11 of papillary urothelial neoplasm of low malignant potential cases, 9/23 of low grade cases, and in 8/15 of high grade cases, and was negative in the one case of papilloma.

It was observed in 2/2 of Tis stage, 4/14 of cases with Ta stage, 9/21 of T1 stage, and 6/11 of T2 stage.

It was negative in the 2 cases of T4.

Statistically Bcl-2 over-expression was not significantly related to the age and sex of the patients, as well as the grade, and stage of the tumors.

However, it was mainly found in the 6th decade of life (42.8%), in males (90.5%), in low grade (42.9%), and in stage T1 (42.9%).

Conclusion: Bcl2 over-expression was found in 42% of bladder urothelial tumors.

Bcl2 over-expression mainly was observed in the 6th decade of life (42.8%), in males (90.5%), in low grade carcinoma (42.9%), and stage T1 (42.9%).

Age and sex of the patients, and grade, and stage of the tumors had no significant correlation with Bcl2 over-expression.