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Insulin resistance in chronic hepatitis c virus patients receiving direct acting antiviral drugs
المؤلفون المشاركون
al-Din, Zaynab Ahmad Ali
Safwat, Islam
Abd al-Rahman, Yasir Umar
Abd al-Aziz, Muhammad Said
Jurj, Imad Nabil
المصدر
Journal of the Egyptian Society of Parasitology
العدد
المجلد 48، العدد 1 (30 إبريل/نيسان 2018)، ص ص. 15-20، 6ص.
الناشر
الجمعية المصرية لعلم الطفيليات
تاريخ النشر
2018-04-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Association between chronic hepatitis C (CHC) infection and insulin resistance (IR) is still challenging.
The study assessed the impact of using direct acting antivirals (DAAs) on IR and the effect of IR on the treatment response.
A total of 101 Egyptian patients with CHC who were eligible to Sofosbuvir based treatment were prospectively involved.
All the patients were subjected to baseline liver function test, fasting and post prandial blood glucose, fasting insulin, quantitative HCV PCR and abdominal ultrasound.
All the patients received sofosbuvir and daclatasvir with or without ribavirin for 12 weeks.
HOMA-IR evaluated IR, both at baseline and at the end of treatment.
The results showed that patients' mean age was 48.59±10.56 years; with female dominance (58.4 %).
An overall sustained response (SVR) was successfully achieved in 96 patients (95.04 %).
Baseline IR (defined as HOMA-IR >2) was identified in 64 patients (63.4 %) with a median value of 3.07.
Patients with positive sustained virologic response (SVR) had lower median values of HOMA-IR than those with negative SVR; both at baseline and the end of treatment (p = 0.004, p = 0.04; respectively).
By the end of treatment, ALT, AST, and FBG showed a significant decrease (p = 0.0001).
Fasting insulin and HOMA-IR showed a slight improvement (p > 0.05).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Din, Zaynab Ahmad Ali& Safwat, Islam& Abd al-Rahman, Yasir Umar& Abd al-Aziz, Muhammad Said& Jurj, Imad Nabil. 2018. Insulin resistance in chronic hepatitis c virus patients receiving direct acting antiviral drugs. Journal of the Egyptian Society of Parasitology،Vol. 48, no. 1, pp.15-20.
https://search.emarefa.net/detail/BIM-901549
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Din, Zaynab Ahmad Ali…[et al.]. Insulin resistance in chronic hepatitis c virus patients receiving direct acting antiviral drugs. Journal of the Egyptian Society of Parasitology Vol. 48, no. 1 (Apr. 2018), pp.15-20.
https://search.emarefa.net/detail/BIM-901549
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Din, Zaynab Ahmad Ali& Safwat, Islam& Abd al-Rahman, Yasir Umar& Abd al-Aziz, Muhammad Said& Jurj, Imad Nabil. Insulin resistance in chronic hepatitis c virus patients receiving direct acting antiviral drugs. Journal of the Egyptian Society of Parasitology. 2018. Vol. 48, no. 1, pp.15-20.
https://search.emarefa.net/detail/BIM-901549
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 19-20
رقم السجل
BIM-901549
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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