The effect of interferon-beta on oxidative stress in patients with multiple sclerosis
العناوين الأخرى
تأثير إنترفيرون-بيتا على حالة الإجهاد التأكسدي في مرضى تصلب الأعصاب المتعدد
المؤلف
المصدر
Annals of the College of Medicine Mosul
العدد
المجلد 40، العدد 2 (31 ديسمبر/كانون الأول 2018)، ص ص. 18-23، 6ص.
الناشر
تاريخ النشر
2018-12-31
دولة النشر
العراق
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective: To assess the effect of interferon–beta on oxidative stress and total antioxidant status in patients with multiple sclerosis (MS).
Design: Case-control study.
Setting: College of Medicine and Ibn-Sina Teaching Hospital, Mosul.
Methodology: The study included 40 female patients with MS.
They divided into 2 groups of 20 patients each.
Group one included newly diagnosed MS patients and group 2 with relapsing–remitting multiple sclerosis (RRMS) in remission phase, who were on interferon therapy.
Another twenty apparently healthy females, age matched with the patients, were considered as a control.
Malondyaldehyde (MDA) and total antioxidant status (TAS) were measured in all groups.
Results: MDA values of both patients groups (1.48±0.59 µmol/l and 1.00±0.49 µmol/l, respectively), were significantly higher than those of the control group (0.60±0.18 µmol/l) (p<0.001).
MDA values were significantly higher in newly diagnosed group than of RRMS 0.001).
The TAS values of both patients groups (0.91±0.26 mmol/l and 1.43±0.20 mmol/l, respectively) were significantly lower than those of the control group (2.14±0.21 mmol/l), (p<0.001).
TAS values of the newly diagnosed patients were significantly lower than those of the patients group with RRMS on interferon thera patients group (p<0.001).
Conclusion: MS patients have higher levels of MDA and lower levels of TAS than the control group.
The newly diagnosed patients have significantly higher levels of MDA and lower TAS than RRMS patients on interferon-beta therapy.
This result may give a new insight about interferon being effective in management of MS by acting as antioxidant.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd Allah, Qasim Salih. 2018. The effect of interferon-beta on oxidative stress in patients with multiple sclerosis. Annals of the College of Medicine Mosul،Vol. 40, no. 2, pp.18-23.
https://search.emarefa.net/detail/BIM-901717
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd Allah, Qasim Salih. The effect of interferon-beta on oxidative stress in patients with multiple sclerosis. Annals of the College of Medicine Mosul Vol. 40, no. 2 (Dec. 2018), pp.18-23.
https://search.emarefa.net/detail/BIM-901717
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd Allah, Qasim Salih. The effect of interferon-beta on oxidative stress in patients with multiple sclerosis. Annals of the College of Medicine Mosul. 2018. Vol. 40, no. 2, pp.18-23.
https://search.emarefa.net/detail/BIM-901717
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 22-23
رقم السجل
BIM-901717
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر