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Inhibitory effect of bee venom against potassium bromate causing genetic toxicity and biochemical alterations in mice
المؤلفون المشاركون
Abd al-Munim, Umaymah M. al-Sayyid
Abd al-Qadir, Hibah A. M.
Abd al-Rahim, Abir H.
Abd al-Rauf, Amirah
المصدر
Journal of the Arab Society for Medical Research
العدد
المجلد 13، العدد 2 (31 ديسمبر/كانون الأول 2018)، ص ص. 89-98، 10ص.
الناشر
تاريخ النشر
2018-12-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background/aim Bee venom (BV) therapy is a highly effective treatment, capable of improving one’s health.
The present study attempts to assess the effect of BV on the toxicity of oral administration of potassium bromate (KBrO3) which has been widely used in food and cosmetic industries.
Materials and methods Sixty adult male mice were gavaged with KBrO3 at two doses (100 and 200 mg/kg body weight) for 10 days.
Afterwards, BV at a dose of 120 μg/kg body weight was injected subcutaneously three times per week for two successive weeks.
The genetic study was performed using chromosomal aberration and micronucleus formation in the bone marrow, DNA fragmentation in liver cells and by sperm analysis.
In addition, serum biochemical markers such as catalase and malondialdehyde, kidney, and liver functions were assessed.
Results The results have shown that KBrO3 caused DNA damage that represented the increase in the frequencies of chromosome abnormalities, micronuclei formation, percentage of DNA fragmentation, and sperm morphological abnormalities.
Meanwhile, the results showed that KBrO3 exhibited severe toxicity for antioxidant activities for liver and kidney functions.
Conversely, BV significantly decreased the frequencies of DNA damage in all aforementioned parameters induced by KBrO3.
In addition, it improved the antioxidant activities and the function of the liver and kidneys.
Conclusion BV has a potent ameliorating effect against the KBrO3 hazard impacts in animal tissues especially at higher doses.
This observation indicated that BV could be a potential therapeutic agent in the treatment of KBrO3 risk.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Rahim, Abir H.& Abd al-Munim, Umaymah M. al-Sayyid& Abd al-Qadir, Hibah A. M.& Abd al-Rauf, Amirah. 2018. Inhibitory effect of bee venom against potassium bromate causing genetic toxicity and biochemical alterations in mice. Journal of the Arab Society for Medical Research،Vol. 13, no. 2, pp.89-98.
https://search.emarefa.net/detail/BIM-901989
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Rahim, Abir H.…[et al.]. Inhibitory effect of bee venom against potassium bromate causing genetic toxicity and biochemical alterations in mice. Journal of the Arab Society for Medical Research Vol. 13, no. 2 (Jul. / Dec. 2018), pp.89-98.
https://search.emarefa.net/detail/BIM-901989
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Rahim, Abir H.& Abd al-Munim, Umaymah M. al-Sayyid& Abd al-Qadir, Hibah A. M.& Abd al-Rauf, Amirah. Inhibitory effect of bee venom against potassium bromate causing genetic toxicity and biochemical alterations in mice. Journal of the Arab Society for Medical Research. 2018. Vol. 13, no. 2, pp.89-98.
https://search.emarefa.net/detail/BIM-901989
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 69-68
رقم السجل
BIM-901989
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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