Analysis of the oxidative stress parameters in testicular, hepatic and renal tissues homogenates of albino rats after administration of imatinib at peripuberty

العناوين الأخرى

تحليل مؤشرات الكرب التأكسدي في مزيج أنسجة الخصية و الكبد والكلى لدى الجرذان بعد التجريع بالايماتنب

المؤلفون المشاركون

al-Allaf, Lama Ibrahim Khalil
al-Ashshu, Hafiz Ali Husayn

المصدر

Rafidain Journal of Science

الناشر

جامعة الموصل كلية العلوم

تاريخ النشر

2018-10-31

دولة النشر

العراق

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري

الملخص الإنجليزي

Background : Targeted small molecule drugs have revolutionized treatment of chronic myelogenous leukemia (CML) over the last two decades.

The safety zone of imatinib, and specifically its relevancy to organ toxicity, has been discussed in a controversial manner in current years.

There is a little data on the contribution of oxidative stress in imatinib induced organ toxicities Objectives : This work aims to analyze the possible role of oxidative stress in the occurrence of testicular, hepatic and renal toxicities induced by imatinib (if present) by analyzing some parameters including glutathione (GSH), malondialdehyde (MDA) levels in their homogenates.

Study setting and design: This experimental study was conducted on male Albino rats (purchased from Animal Houses of both Mosul Medical College, and Veterinary College, University of Mosul, Mosul, Northern Iraq).

Methods : This work included 40- 45 days aged rats (at peripuberty) (n = 8) which administered a single daily dose of 200mg/kg of imatinib mesylate for 30 days (100mg capsule, Glivec®, STI 571; Novartis) bought from Ibn-Sena Teaching Hospital, Mosul, Northern Iraq, or bought from some private pharmacies and were dissolved in distilled water (D.W) and given orally by gavage with 24 gage needle.

Another group of 8 rats were administered with D.W represents an age matched control.

Testes, livers, parts and kidneys were collected from all rats.

Tissue GSH, MDA concentrations in the homogenates of the three organs were determined by spectrophotometer according to the methods described.

Results : All rats survived the experimental period.

This study revealed a decrease in value of GSH in the testicular and hepatic tissues of the treated rats, however, the concentrations of this antioxidant in renal tissue were higher than that of control ones.

Briefly, imatinib induced an elevation of MDA productions in both testicular and hepatic tissues when compared to the control group.

MDA concentrations in renal homogenates in the treated group were lower than that of control ones.

Conclusion : Imatinib induced a decrease in the level of GSH and increased in level of MDA in testicular, hepatic homogenates indicating its oxidative effect.

نوع البيانات

أوراق مؤتمرات

رقم السجل

BIM-902275

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