Impact of PAI-1 4G5G and C > G polymorphisms in acute ST elevation myocardial infarction and stable angina patients : a single center Egyptian study
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 19، العدد 4 (31 أكتوبر/تشرين الأول 2018)، ص ص. 325-331، 7ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2018-10-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Many genetic factors, including polymorphisms in the genes regulating blood coagulation and fibrinolysis have been proposed as risk factors for coronary artery disease (CAD).
PAI-1 is the chief inhibitor of tissue plasminogen activator and urokinase plasminogen activator.
PAI-1 has a crucial role in regulation of fibrinolysis.
Aim of the study: Is to investigate the association between Plasminogen activator inhibitor-1 (PAI-1) 4G/5G, PAI-1C/G polymorphisms and CAD.
In addition, studying the relation of these polymorphisms to the level of active PAI-1 in Egyptian patients presenting to a single tertiary center in Cairo.
Subjects and methods: One hundred and forty-four patients were included in this study: 42 STEMI (ST elevation myocardial infarction) patients, 63 stable angina patients, and 39 as a control group.
Detection of PAI-1 4G/5G and C > G polymorphisms was done using allele specific polymerase chain reaction and restriction fragment length polymorphism (RFLP) respectively.
Plasma plasminogen activator inhibitor- 1 activity was detected using enzyme linked immunosorbent assay (ELISA).
Results: In the studied CAD patients, PAI-14G/5G polymorphism showed 31.7%, and 68.3% for 5G/5G, and (4G/5G + 4G/4G) respectively; however for the control group, 5G/5G, and (4G/5G + 4G/4G) were detected in 21.6%, and 78.4% respectively (p value 0.59).
The genotypic frequencies for PAI-1C/G in CAD patients accounted for 27% (CC), 73% (CG + GG); while in the control group these frequencies were 35.3%, and 64.7% respectively (p value 1.43).
Conclusion: No significant association between PAI-1 4G/5G and C > G polymorphisms and the risk of coronary artery disease or the activity level of PAI-1 among the studied Egyptian population sample.
However, STEMI patients showed significant presence of combined mutant allele of both genes more frequently.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Wakil, Hanan& Suwaylim, Nadiyah I.& Khalid, Muhammad& Abd al-Bari, Akram. 2018. Impact of PAI-1 4G5G and C > G polymorphisms in acute ST elevation myocardial infarction and stable angina patients : a single center Egyptian study. The Egyptian Journal of Medical Human Genetics،Vol. 19, no. 4, pp.325-331.
https://search.emarefa.net/detail/BIM-902436
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Wakil, Hanan…[et al.]. Impact of PAI-1 4G5G and C > G polymorphisms in acute ST elevation myocardial infarction and stable angina patients : a single center Egyptian study. The Egyptian Journal of Medical Human Genetics Vol. 19, no. 4 (Oct. 2018), pp.325-331.
https://search.emarefa.net/detail/BIM-902436
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Wakil, Hanan& Suwaylim, Nadiyah I.& Khalid, Muhammad& Abd al-Bari, Akram. Impact of PAI-1 4G5G and C > G polymorphisms in acute ST elevation myocardial infarction and stable angina patients : a single center Egyptian study. The Egyptian Journal of Medical Human Genetics. 2018. Vol. 19, no. 4, pp.325-331.
https://search.emarefa.net/detail/BIM-902436
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 330-331
رقم السجل
BIM-902436
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر