New insights into smudge cell percentage in chronic lymphocytic leukemia : a novel prognostic indicator of disease burden
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 19، العدد 4 (31 أكتوبر/تشرين الأول 2018)، ص ص. 409-415، 7ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2018-10-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Percentage of smudge cells in CLL patients has recently been reported as a novel prognostic factor.
Objectives: To investigate the impact of smudge cells percentage on the clinicolaboratory data of CLL patients and to evaluate the relationship between it and other prognostic factors in CLL.
Methods: Ninety adults with CLL were enrolled.
Smudge cells percentage was calculated by microscopic evaluation of blood smears.
Testing of CD38 expression was done by immunophenotyping and detection of ATM, P53 deletions and trisomy 12 were performed using fluorescent in situ hybridization (FISH) Results: Lower smear cells percentage (<30%) was significantly correlated with age, lymphadenopathy, organomegaly and advanced staging.
It was also associated with high TLC, low hemoglobin and platelets count and high absolute and atypical lymphocytic count.
Correlation studies with other prognostic factors revealed an association between low smear cells percentage and CD38 expression, short LDT, P53 and ATM deletions.
Logistic regression analysis was also done to provide complementary prognostic information identifying the significant independent factors that predict low smear cell percentage.
Conclusion: low percentage of smudge cells (<30%) could be considered as an adverse prognostic predictor being associated with high risk markers in CLL.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muhammad, Amal Abd al-Hamid& Safwat, Nismah Ahmad. 2018. New insights into smudge cell percentage in chronic lymphocytic leukemia : a novel prognostic indicator of disease burden. The Egyptian Journal of Medical Human Genetics،Vol. 19, no. 4, pp.409-415.
https://search.emarefa.net/detail/BIM-902642
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muhammad, Amal Abd al-Hamid& Safwat, Nismah Ahmad. New insights into smudge cell percentage in chronic lymphocytic leukemia : a novel prognostic indicator of disease burden. The Egyptian Journal of Medical Human Genetics Vol. 19, no. 4 (Oct. 2018), pp.409-415.
https://search.emarefa.net/detail/BIM-902642
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muhammad, Amal Abd al-Hamid& Safwat, Nismah Ahmad. New insights into smudge cell percentage in chronic lymphocytic leukemia : a novel prognostic indicator of disease burden. The Egyptian Journal of Medical Human Genetics. 2018. Vol. 19, no. 4, pp.409-415.
https://search.emarefa.net/detail/BIM-902642
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 415
رقم السجل
BIM-902642
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر