Comparative study to evaluate the efficacy of hydrogen sulfide separately or in combination with some antioxidants against myocardial dysfunction in irradiated rats
المؤلفون المشاركون
Mazin, G. M. A.
Abd al-Munim, H. A.
المصدر
Arab Journal of Nuclear Sciences and Applications
العدد
المجلد 52، العدد 4 (31 أكتوبر/تشرين الأول 2019)، ص ص. 167-174، 8ص.
الناشر
الجمعية المصرية للعلوم النووية و تطبيقاتها
تاريخ النشر
2019-10-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Hydrogen sulfide (H2S) is an endogenously produced gaseous second messenger capable of mitigating pathological cardiac remodeling by regulating several cellular processes including fibrosis, hypertrophy, apoptosis, and inflammation.
this study was dedicated to determine the cardio-protective efficacy of hydrogen sulfide alone or in combination with L-carnitine, co-enzyme Q10 or alpha lipoic acid against cardiovascular disease that occurred as a result of γ-irradiation in male albino rats.
the obtained results revealed a remarkable change in all studied parameters after exposure to γ-radiation.
However, irradiated rats treated by H2S showed a significant (p<0.05) decrease in the activities of serum cardiac enzymes (CK, CK-MB, LDH & AST) and in the concentration of heart fatty acid binding protein (H-FABP) and endothelin-1 as well as the levels of cytokines profile (IL-1β, IL-10 & TNF-α) associated with a remarkable decrease in the level of heart TBARS than those in irradiated rats.
On the other hand, H2S caused a significant (p<0.05) increase in the level of serum TNO as well as in the heart GSH content and GPx activity than those of irradiated rats.
Additive of L-carnitine or Co-Q10 to H2S produced considerable improvement in all studied parameters, which become more pronounced in case of L-carnitine but less in case of Co-Q10 while, the addition of α-lipoic acid did not induce any noticeable changes.
It is concluded that the use of L-carnitine increases efficacy of H2S and could exhibit modulatory effects on γ-radiation-induced cardiovascular disease in rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mazin, G. M. A.& Abd al-Munim, H. A.. 2019. Comparative study to evaluate the efficacy of hydrogen sulfide separately or in combination with some antioxidants against myocardial dysfunction in irradiated rats. Arab Journal of Nuclear Sciences and Applications،Vol. 52, no. 4, pp.167-174.
https://search.emarefa.net/detail/BIM-903445
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mazin, G. M. A.& Abd al-Munim, H. A.. Comparative study to evaluate the efficacy of hydrogen sulfide separately or in combination with some antioxidants against myocardial dysfunction in irradiated rats. Arab Journal of Nuclear Sciences and Applications Vol. 52, no. 4 (Oct. 2019), pp.167-174.
https://search.emarefa.net/detail/BIM-903445
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mazin, G. M. A.& Abd al-Munim, H. A.. Comparative study to evaluate the efficacy of hydrogen sulfide separately or in combination with some antioxidants against myocardial dysfunction in irradiated rats. Arab Journal of Nuclear Sciences and Applications. 2019. Vol. 52, no. 4, pp.167-174.
https://search.emarefa.net/detail/BIM-903445
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 172-174
رقم السجل
BIM-903445
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر