Synthesis and characterization of some heterocyclic compounds from 6-chloro-1,3-benzothiazole-2-thiol

الملخص EN

This research involved some of heterocyclic derivatives from 6-chloro-1,3-benzothiazole-2-thiol by the reacted of this compound with chloro ethyl acetate to gave compound [1] in which reacted with hydrazine to gave compound [2] , the last compound will react with several reagents to gave a new series of heterocyclic derivatives in which compound [2] reacted with different aromatic aldehydes in ethanol to gave Schif bases [3,4] .

The last compounds convert to β-lactam [5,6] by the reaction between Schiff bases and chloro acetyl chloride .

Compound [2] react with CS2 ,KOH to gave a new derivative compound [7] in which reacted with hydrazine gave compound [8] and reacted with different aromatic aldehydes to gave another kind of Schiff bases [9,10] and cyclization of the last compound with 2-mercapto acetic acid to gave [11,12] .

Reaction of compound [2] with phenyl isothiocyanate to gave compound [13] and cyclization of [13] by NaOH gave several new heterocyclic derivatives [14], these all compounds were characterized by their melting points, FTIR and 1H-NMR spectra for some of them .