Cord blood leptin, osteocalcin, and tumor necrosis factor alpha levels in gestational diabetic versus normal pregnancy : impact on neonatal outcome in a birth cohort
المؤلفون المشاركون
Bahceciler, Nerin Nadir
Galip, Nilufer
Dalkan, Ceyhun
Uncu, Murat
Yaici, Ayyub
Akman, Ipek
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 20، العدد 7 (31 يوليو/تموز 2018)، ص ص. 1-8، 8ص.
الناشر
تاريخ النشر
2018-07-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background: Although gestational diabetes may result in elevated leptin, osteocalcin, and TNF-α (Tumor necrosis factor) levels, impact of those parameters on the neonatal outcome is not well established.
Objectives: The aim of the current study was to evaluate whether cord blood leptin, TNFα(Tumor necrosis factor), and osteocalcin have a predictive value for neonatal complications due to maternal GDM (Gestational Diabetes Mellitus).
Methods: This cohort study was performed at Near East University Hospital, Nicosia, Cyprus.
All pregnant females under follow-up of the department of Obstetrics and Gynecology between years 2010 and 2012 were invited to participate.
Those, who gave consent, were enrolled.
Expecting mothers were categorized as GDM and normal pregnancy.
41 (21.5%) of the pregnancies were GDM and 159 (78.5%) were normal.
Cord blood samples were obtained at delivery.
Osteocalcin, leptin, and TNF-αlevels and neonatal complications were evaluated thereafter.
Results: Comparison of pregnancy complications between groups revealed no significant differences except for more frequent maternal hypothyroidism in the GDM group (P < 0.001).
The GDM group’s cord blood osteocalcin levels (44.69 ± 27.6 ng/mL and 35.23±22.9 ng/mL in the control group (P : 0.037)) and frequency of neonatal hypoglycemia were significantly higher than controls (P : 0.047), whereas cord blood TNF α and leptin levels were not statistically different (P > 0.05).
Newborns with hypoglycemia showed higher cord blood osteocalcin, TNF-α, and leptin.
In addition, osteocalcin levels were significantly higher in cord blood of LGA babies born from GDM mothers (50.41 ± 32.79 and 35.19 ± 20.18 ng/mL).
Conclusions: In this study, cord blood leptin, osteocalcin, and TNF-α were significantly correlated with neonatal hypoglycemia.
Moreover, cord blood osteocalcin levels were significantly higher in the GDM group.
This increase in osteocalcin in the GDM group, may be related to the regulation of blood glucose levels by osteocalcin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dalkan, Ceyhun& Uncu, Murat& Galip, Nilufer& Yaici, Ayyub& Bahceciler, Nerin Nadir& Akman, Ipek. 2018. Cord blood leptin, osteocalcin, and tumor necrosis factor alpha levels in gestational diabetic versus normal pregnancy : impact on neonatal outcome in a birth cohort. Iranian Red Crescent Medical Journal،Vol. 20, no. 7, pp.1-8.
https://search.emarefa.net/detail/BIM-903555
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dalkan, Ceyhun…[et al.]. Cord blood leptin, osteocalcin, and tumor necrosis factor alpha levels in gestational diabetic versus normal pregnancy : impact on neonatal outcome in a birth cohort. Iranian Red Crescent Medical Journal Vol. 20, no. 7 (Jul. 2018), pp.1-8.
https://search.emarefa.net/detail/BIM-903555
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dalkan, Ceyhun& Uncu, Murat& Galip, Nilufer& Yaici, Ayyub& Bahceciler, Nerin Nadir& Akman, Ipek. Cord blood leptin, osteocalcin, and tumor necrosis factor alpha levels in gestational diabetic versus normal pregnancy : impact on neonatal outcome in a birth cohort. Iranian Red Crescent Medical Journal. 2018. Vol. 20, no. 7, pp.1-8.
https://search.emarefa.net/detail/BIM-903555
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 7-8
رقم السجل
BIM-903555
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر