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Histopathological effects of 5-fluorouracil on the liver of male rabbits (with and without folic acid administration)
المؤلف
المصدر
العدد
المجلد 16، العدد 1 (31 ديسمبر/كانون الأول 2016)، ص ص. 59-66، 8ص.
الناشر
تاريخ النشر
2016-12-31
دولة النشر
العراق
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The objective of this study is to evaluate the effects of 5-fluorouracil (5-FU) on the liver tissue of rabbits, as well as the effect of folic acid on the effectiveness of 5-FU on the rabbit's liver.
Materials and Methods: In this study nine adult male rabbits ,aged about 3 months were used and divided into three main groups .Group 1 : served as a control group and received normal saline only.Group 2 : treated by 5-fluorouracil , 10 mg / kg intraperitonealy twice weekly for 8 weeks.
Group 3 : treated by 5-fluorouracil , 10 mg / kg intraperitonealy twice weekly for 8 weeks with 5mg of folic acid orally twice weekly for 8 weeks .The animals were sacrificed and livers were excised and processed for histological study.
Results: The liver of the treated group 2 shows disturbance in the architecture of hepatic lobule , swelling and vacuola-tion of the hepatocytes ,with ballooning degeneration and areas of necrosis.
Congestion in the portal blood vessels and congestion in the central vein , together with congestion and dilatation of the sinusoids.
Infiltra-tion of mononuclear inflammatory cells in the portal area and around the central vein .While liver sections of group 3 show slight disturbance in hepatic cords architecture , hepatocytes showed no swelling and few vacuolation in their cytoplasm ,mononuclear cells infilitration mainly in the portal area and in lesser de-gree than that found in group 2 ,necrosis were not present.
Conclusion:Toxic effect of 5-FU was observed on the liver tissue of rabbits , and an effective drugs must be applied with anticancer agents to improve liver function .
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ahmad, Makarem Hamid. 2016. Histopathological effects of 5-fluorouracil on the liver of male rabbits (with and without folic acid administration). al-Rafidain Dental Journal،Vol. 16, no. 1, pp.59-66.
https://search.emarefa.net/detail/BIM-903900
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ahmad, Makarem Hamid. Histopathological effects of 5-fluorouracil on the liver of male rabbits (with and without folic acid administration). al-Rafidain Dental Journal Vol. 16, no. 1 (2016), pp.59-66.
https://search.emarefa.net/detail/BIM-903900
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ahmad, Makarem Hamid. Histopathological effects of 5-fluorouracil on the liver of male rabbits (with and without folic acid administration). al-Rafidain Dental Journal. 2016. Vol. 16, no. 1, pp.59-66.
https://search.emarefa.net/detail/BIM-903900
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 66
رقم السجل
BIM-903900
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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