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Biologically produced nano-selinum reduces initiation stage of diethyl nitrosamine hepatocarcinogenesis in rats
العناوين الأخرى
جزيئات السيلينوم متناهيه الصغر المنتجة بيولوجيا تقلل مرحلة البدء في سرطان الكبد بالداياثيل نيتروزامين
المؤلفون المشاركون
Shukri, Mustafa
Abduh, Walid
Abd al-Hadi, Dua H.
Ghazi, Imad Wadid
Id, Yahya Z.
المصدر
Assiut Veterinary Medical Journal
العدد
المجلد 64، العدد 156 (31 يناير/كانون الثاني 2018)، ص ص. 69-80، 12ص.
الناشر
تاريخ النشر
2018-01-31
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Biologically produced Nano-selenium (Nano-se) considers one of the less toxic element in comparison with the other forms of selenium.
The present study evaluated the protective effect of biologically Nano-se against early hepatocarcinogenesis induced by diethyl nitrosamine (DEN) for 1 week in rats.
Forty male Wister rats were divided into four groups as follows: Group 1 treated with intraperitoneal (i.p.) injection with physiological saline once and kept as control; group 2 treated with DEN alone (200 mg/kg) i.p.
injection once; group 3 treated with both DEN and Nano-Se and group 4 treated with Nano-Se alone (0.5 mg/kg) orally by gastric intubation.
DEN administration did not alter the erythrogram but induced significant changes in leukogram represented by increase in total leukocytic count (TLC), neutrophil and monocyte cell counts together with significant reduction in lymphocyte and eosinophil cells count (P ≤ 0.05).
DEN induced hepatotoxicity noticed through an elevation of serum hepatic enzymes such as AST, ALT and γ-GT.
Additionally, an increase in the oxidative stress marker as malondialdehyde content (MDA) and reduction of antioxidant parameters such as catalase (CAT) and reduced glutathione (GSH) were observed.
Moreover, DEN was associated with the formation of putative hepatic foci indicated with over expression of glutathione transeferase –placental form (GST-P) immunostaining.
Interestingly, Nano-Se clearly alleviated the negative impacts of DEN induced hepatotoxicity via returning leukogram to normal condition, suppressed the elevated of serum hepatic enzymes, oxidative stress markers, decrease positive GST-P foci and remarkably increased the antioxidant capacity.
Therefore, biological produced Nano-se might be considered as an effective strategy in hepatic cancer chemoprevention.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Hadi, Dua H.& Ghazi, Imad Wadid& Abduh, Walid& Id, Yahya Z.& Shukri, Mustafa. 2018. Biologically produced nano-selinum reduces initiation stage of diethyl nitrosamine hepatocarcinogenesis in rats. Assiut Veterinary Medical Journal،Vol. 64, no. 156, pp.69-80.
https://search.emarefa.net/detail/BIM-909123
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Hadi, Dua H.…[et al.]. Biologically produced nano-selinum reduces initiation stage of diethyl nitrosamine hepatocarcinogenesis in rats. Assiut Veterinary Medical Journal Vol. 64, no. 156 (Jan. 2018), pp.69-80.
https://search.emarefa.net/detail/BIM-909123
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Hadi, Dua H.& Ghazi, Imad Wadid& Abduh, Walid& Id, Yahya Z.& Shukri, Mustafa. Biologically produced nano-selinum reduces initiation stage of diethyl nitrosamine hepatocarcinogenesis in rats. Assiut Veterinary Medical Journal. 2018. Vol. 64, no. 156, pp.69-80.
https://search.emarefa.net/detail/BIM-909123
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
رقم السجل
BIM-909123
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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