Therapeutic potential of the methanolic extract of Lepidium sativum seeds on mice infected with Trypanosoma evansi
المؤلفون المشاركون
al-Maliki, Isam S.
al-Utaybi, Mamduh S. A.
al-Qurayshi, Salih
Abd al-Baqi, Abd al-Azim S.
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 26، العدد 7 (30 نوفمبر/تشرين الثاني 2019)، ص ص. 1473-1477، 5ص.
الناشر
تاريخ النشر
2019-11-30
دولة النشر
السعودية
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
The present study aimed to investigate the therapeutic potential of the methanolic extract of Lepidium sativum seeds in mice experimentally infected with Trypanosoma evansi.
A total of thirty-two male Swiss albino mice were randomly divided into four groups: the first group was the normal control, while the second, third and fourth groups were infected intraperitoneally with 1 × 104 trypanosomes.
The third and fourth groups were treated with 100 μl of Lepidium sativum seed extract (LSSE) at a dose of 200 mg/kg body weight intraperitoneally (infected + LSSEI) and orally (infected + LSSEO) respectively, once a day, for a period of four days.
Parasitaemia was found to be significantly raised in the untreated infected group, reaching 2 × 107 at day 4 post-infection, but was significantly reduced by 65.5% and 88% in the mice treated orally and intraperitoneally with LSSE, respectively.
The erythrocyte count, HCT, haemoglobin content, leucocyte count and the percentage of lymphocytes was significantly reduced in the untreated infected group, while the treatment with LSSE returned these parameters to their pre-infection values.
In addition, our study proved that LSSE provided protection against liver tissue damage and decreased the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT).
The present study also established that intraperitoneal injection of LSSE is more effective than oral administration in the treatment of trypanosome infection in mice.
In conclusion, the infection caused haematological, biochemical and histological changes that were ameliorated following treatment with LSSE.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Utaybi, Mamduh S. A.& al-Qurayshi, Salih& al-Maliki, Isam S.& Abd al-Baqi, Abd al-Azim S.. 2019. Therapeutic potential of the methanolic extract of Lepidium sativum seeds on mice infected with Trypanosoma evansi. Saudi Journal of Biological Sciences،Vol. 26, no. 7, pp.1473-1477.
https://search.emarefa.net/detail/BIM-910159
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Utaybi, Mamduh S. A.…[et al.]. Therapeutic potential of the methanolic extract of Lepidium sativum seeds on mice infected with Trypanosoma evansi. Saudi Journal of Biological Sciences Vol. 26, no. 7 (Nov. 2019), pp.1473-1477.
https://search.emarefa.net/detail/BIM-910159
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Utaybi, Mamduh S. A.& al-Qurayshi, Salih& al-Maliki, Isam S.& Abd al-Baqi, Abd al-Azim S.. Therapeutic potential of the methanolic extract of Lepidium sativum seeds on mice infected with Trypanosoma evansi. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 7, pp.1473-1477.
https://search.emarefa.net/detail/BIM-910159
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1477
رقم السجل
BIM-910159
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر