In vivo pharmacological investigation of Monotheca buxifolia and Bosea amherstiana using animal models

المؤلفون المشاركون

Khan, Shahid Allah
Rahman, Khaista
Khan, Wasim Allah
Ansari, Muhammad Javed
Hasan, Said
Linfang, Huang
Anjum, Sayyid Ishtiaq
Qamar, Rabiah
Man, Shad
Shah, Aishah Halim
Nabi, Ghulam
Ahmad, Iftikhar
Ahmad, Bashir

المصدر

Saudi Journal of Biological Sciences

العدد

المجلد 26، العدد 7 (30 نوفمبر/تشرين الثاني 2019)، ص ص. 1602-1606، 5ص.

الناشر

الجمعية السعودية لعلوم الحياة

تاريخ النشر

2019-11-30

دولة النشر

السعودية

عدد الصفحات

5

التخصصات الرئيسية

الأحياء

الموضوعات

الملخص EN

Experimental based evidence suggests that most of the medicinal plants possess wide-ranging pharmacological and biological activities that may possibly use in treatment of inflammation-related diseases.

The current study was aimed to explore the acute toxicity, analgesic, sedative and antipyretic activities of Monotheca buxifolia and Bosea amherstiana in mices.

In vivo experimental models were used in this study.

Acute toxicity was evaluated for 24 h’ interval at concentration of 500, 1000, 1500 and 2000 mg/kg.

The analgesic activity was estimated by acetic acid induced writhing test.

White wood apparatus enclosed in stainless steel was used for sedative experiment and antipyretic activity was evaluated in brewer’s yeast induced hyperthermic at 50, 100 and 150 mg/kg i.p.

Both plants were found safe at all tested doses.

Monotheca buxifolia and Bosea amherstiana dose-dependently reduced abdominal constrictions in mice.

Both plants exhibited significant (P < 0.0001) sedative effects in dose of 50, 150 and 150 mg/kg.

Both plants markedly (P < 0.0001) reduced yeast induced hyperthermia.

The inhibitions were dose-dependent and remained significant up to five hours of administration.

These investigational results have linked a pharmacological indication for the traditional claim of the drugs to be used as an anti-inflammatory, analgesics and antipyretic agents.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Hasan, Said& Ahmad, Bashir& Khan, Shahid Allah& Linfang, Huang& Anjum, Sayyid Ishtiaq& Ansari, Muhammad Javed…[et al.]. 2019. In vivo pharmacological investigation of Monotheca buxifolia and Bosea amherstiana using animal models. Saudi Journal of Biological Sciences،Vol. 26, no. 7, pp.1602-1606.
https://search.emarefa.net/detail/BIM-910181

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Hasan, Said…[et al.]. In vivo pharmacological investigation of Monotheca buxifolia and Bosea amherstiana using animal models. Saudi Journal of Biological Sciences Vol. 26, no. 7 (Nov. 2019), pp.1602-1606.
https://search.emarefa.net/detail/BIM-910181

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Hasan, Said& Ahmad, Bashir& Khan, Shahid Allah& Linfang, Huang& Anjum, Sayyid Ishtiaq& Ansari, Muhammad Javed…[et al.]. In vivo pharmacological investigation of Monotheca buxifolia and Bosea amherstiana using animal models. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 7, pp.1602-1606.
https://search.emarefa.net/detail/BIM-910181

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 1606

رقم السجل

BIM-910181