The protective effect of vanadium on cyclophosphamide-induced teratogenesis in mouse fetus

المؤلفون المشاركون

Azadbakht, Mehri
al-Rudaini, Amjad Turki

المصدر

مجلة جامعة الكوفة لعلوم الحياة : مجلة علمية محكمة

الناشر

جامعة الكوفة كلية العلوم قسم علوم الحياة

تاريخ النشر

2018-12-31

دولة النشر

العراق

عدد الصفحات

9

التخصصات الرئيسية

الأحياء
علم الحيوان

الموضوعات

• الأجنة
• الفئران
• المعادن الانتقالية
• سيكلوفوسفاميد

الملخص الإنجليزي

Cyclophosphamide(CP) is a chemotherapeutic and immunosuppressive drug used for treatment of neoplastic and some auto-immune diseases, but it has several important adverse effects and can induce external malformations in the fetus.

Different materials can use to avoid or prevent its side effects.

Trace elements as an antioxidant can prevent oxidative stress by binding to free radicals and reduce adverse effects of chemotherapy drugs.

vanadium is present as an ultratrace element has prophylactic effects on teratogenic effects of CP.

The aim of our work was to estimate the vanadium effect on CP-induced macroscopic fetal defects in mice.

In this study pregnant NMRI mice were divided into four groups.

control group received normal saline, CP group received CP (10 mg/kg on 11th GD), V group received vanadium (4mg/kg on 8th,10th and 12th) and V/CP group CP (10 mg/kg on 11th GD) with vanadium (4mg/kg on 8th,10th and 12th) intraperitoneally.

Fetuses were collected on the 19th GD.

Then the weight of fetuses, length of crown-rump, limbs, and tail of fetuses were measured.

The external teratogenesis were investigated by the stereomicroscope.

The results revealed that the CP decreased fetal weight, and also reduced the length, limbs, and tail in fetuses that received only CP (P≤0.05).

In V/CP the reduction in all previous parameters significantly increased compared with CP group.

CP also caused some types of external teratogenesis such as a short neck, short limbs, non-separating fingers and toes from each other and malrotated hind limbs, oligodactyly, kinky tail, reduction in the distribution of hair follicles on the body surface, and hemorrhage on body surface, while did not notice in V/CP group.

On the basis of results, vanadium has a significant prophylactic effect on preventing teratogenesis that induced via CP.

نوع البيانات

أوراق مؤتمرات

رقم السجل

BIM-910799

• APA
• MLA
• AMA