Potential nephroprotectice effect of curcumin against gentamicin induced nephrotoxicity : an experimental study in rats

الملخص EN

Background: Nephrotoxicity is a serious & common side effect of aminoglycoside and is induced by generation of reactive oxygen species.

Emerging evidence reveals that curcumin possesses antioxidant activity, therefore, this research was undertaken to evaluate the potential protective effects of curcumin in amiloration of nephrotoxicity induced by gentamicin in male rats.

Materials and Methods: Eighteen male Spraque-Dawley rats were included in this study.

They were divided randomly into three equal groups (six rats each).

Groups I (Control) received only normal saline i.p, Groups II (GN) received gentamicin (100 mg/kg/day), Group III (GN+CUR) received a combination treatment gentamicin (100 mg/kg/day, i.p) & curcumin (200 mg/kg/day p.o).

The duration of treatment was eight days and at the end of the study, animals were sacrificed and the blood sample was collected for assessment of renal function, blood urea & serum creatinine.

Both kidneys were removed and prepared for a histopathology examination.

Results: blood urea and creatinine were significantly higher (P < .05) in gentamycin treated group (group II) as compared to the control group (group I).

However, the levels of these parameters in group 3 (co-treatment of gentamicin and curcumin) were significantly lower than those in group 2 (P < .05).

Further, the histological score of renal damage was higher in the gentamicin group than in the control group.

Combination treatment of curcumin and gentamicin (groupIII) significantly attenuated the histopathological damage.

Conclusion: Curcumin attenuated gentamicin-induced renal injury in rats’ models.