Potential nephroprotectice effect of curcumin against gentamicin induced nephrotoxicity : an experimental study in rats
المؤلفون المشاركون
Muhammad, Bassim I.
al-Haydari, Karrar K.
Majid, Sahar A.
المصدر
al-Kufa University Journal for Biology
العدد
المجلد 11، العدد 1 (30 يونيو/حزيران 2019)، ص ص. 18-26، 9ص.
الناشر
جامعة الكوفة كلية العلوم قسم علوم الحياة
تاريخ النشر
2019-06-30
دولة النشر
العراق
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Nephrotoxicity is a serious & common side effect of aminoglycoside and is induced by generation of reactive oxygen species.
Emerging evidence reveals that curcumin possesses antioxidant activity, therefore, this research was undertaken to evaluate the potential protective effects of curcumin in amiloration of nephrotoxicity induced by gentamicin in male rats.
Materials and Methods: Eighteen male Spraque-Dawley rats were included in this study.
They were divided randomly into three equal groups (six rats each).
Groups I (Control) received only normal saline i.p, Groups II (GN) received gentamicin (100 mg/kg/day), Group III (GN+CUR) received a combination treatment gentamicin (100 mg/kg/day, i.p) & curcumin (200 mg/kg/day p.o).
The duration of treatment was eight days and at the end of the study, animals were sacrificed and the blood sample was collected for assessment of renal function, blood urea & serum creatinine.
Both kidneys were removed and prepared for a histopathology examination.
Results: blood urea and creatinine were significantly higher (P < .05) in gentamycin treated group (group II) as compared to the control group (group I).
However, the levels of these parameters in group 3 (co-treatment of gentamicin and curcumin) were significantly lower than those in group 2 (P < .05).
Further, the histological score of renal damage was higher in the gentamicin group than in the control group.
Combination treatment of curcumin and gentamicin (groupIII) significantly attenuated the histopathological damage.
Conclusion: Curcumin attenuated gentamicin-induced renal injury in rats’ models.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Majid, Sahar A.& al-Haydari, Karrar K.& Muhammad, Bassim I.. 2019. Potential nephroprotectice effect of curcumin against gentamicin induced nephrotoxicity : an experimental study in rats. al-Kufa University Journal for Biology،Vol. 11, no. 1, pp.18-26.
https://search.emarefa.net/detail/BIM-910853
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Majid, Sahar A.…[et al.]. Potential nephroprotectice effect of curcumin against gentamicin induced nephrotoxicity : an experimental study in rats. al-Kufa University Journal for Biology Vol. 11, no. 1 (2019), pp.18-26.
https://search.emarefa.net/detail/BIM-910853
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Majid, Sahar A.& al-Haydari, Karrar K.& Muhammad, Bassim I.. Potential nephroprotectice effect of curcumin against gentamicin induced nephrotoxicity : an experimental study in rats. al-Kufa University Journal for Biology. 2019. Vol. 11, no. 1, pp.18-26.
https://search.emarefa.net/detail/BIM-910853
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 24-26
رقم السجل
BIM-910853
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر