Beta-cell death andor stress biomarkers in diabetes mellitus type 1
المؤلفون المشاركون
Shit, Madha Muhammad
Khudayr, Hasan Abd Ali
المصدر
al-Kufa University Journal for Biology
العدد
المجلد 11، العدد 1 (30 يونيو/حزيران 2019)، ص ص. 108-119، 12ص.
الناشر
جامعة الكوفة كلية العلوم قسم علوم الحياة
تاريخ النشر
2019-06-30
دولة النشر
العراق
عدد الصفحات
12
التخصصات الرئيسية
الموضوعات
الملخص EN
Diabetes Mellitus type 1 (T1D) occurs due to disturbance intolerance of the immune system and invasion of β-cells by auto-reactive immune T cells and inducing deterioration of β-cells activity and viability and a prolong therapy with external insulin.
This study was aimed to detect the predictive power as well as the degree of correlation of defined glutamic acid decarboxylase autoantibody (GADA), protein tyrosine phosphatase type A2 (IA-2A) and total antioxidant capacity (TAC) biomarkers on β-cells stress and/or death in T1D individuals as well as their first degree relatives (FDRs).
Three groups of T1D patients, FDRs and apparently diseases free subjects had been enrolled in this work and evaluated for their serum GADA, IA-2A, C-peptide and TAC.
The results revealed positive GADA and IA-2A in 88.6% and 40%, respectively, of T1D patients.
The frequency of normal level and mean titer of C-peptide were significantly low among T1D and their FDRs, also the frequency of normal level and mean titer of TAC was significantly low among T1D patients.
However, no significant difference in C-peptide level was noticed between the GADA+ and GADAsubjects with no significant effect of TAC level on the concentration of C-peptide.
Finally, the concentration of C-peptide was significantly lower in IA2-A positive than IA-2-A negative individuals.
In conclusion, GADA, IA-2A and C-peptide combination can suggest the most powerful and cost-effective diagnostic approach in patients with T1D and their FDRs.
In addition, IA-2A in T1D patient’s serum can be predicted for β-cell death and/or stress, however, GADA and TAC was found of no effect on the C-peptide level.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shit, Madha Muhammad& Khudayr, Hasan Abd Ali. 2019. Beta-cell death andor stress biomarkers in diabetes mellitus type 1. al-Kufa University Journal for Biology،Vol. 11, no. 1, pp.108-119.
https://search.emarefa.net/detail/BIM-910915
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shit, Madha Muhammad& Khudayr, Hasan Abd Ali. Beta-cell death andor stress biomarkers in diabetes mellitus type 1. al-Kufa University Journal for Biology Vol. 11, no. 1 (2019), pp.108-119.
https://search.emarefa.net/detail/BIM-910915
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shit, Madha Muhammad& Khudayr, Hasan Abd Ali. Beta-cell death andor stress biomarkers in diabetes mellitus type 1. al-Kufa University Journal for Biology. 2019. Vol. 11, no. 1, pp.108-119.
https://search.emarefa.net/detail/BIM-910915
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 117-119
رقم السجل
BIM-910915
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر