Transcriptional profiling of livers from different strain of mice treated with Asparaginase
المؤلف
al-Baghdadi, Rana Jabir Tarish
المصدر
al-Qadisiyah Journal of Veterinary Medicine Sciences
الناشر
جامعة القادسية كلية الطب البيطري
تاريخ النشر
2018-12-31
دولة النشر
العراق
عدد الصفحات
4
التخصصات الرئيسية
الملخص الإنجليزي
Asparaginase (ASNase) is widely used to treat acute lymphoblastic leukemia (ALL) in children but it causes metabolic complications related to liver toxicity.
ASNase results in the synthesis of some factors such as ATF4.
The eIF2-ATF4 pathway is essential for cell survival during amino acid starvation conditions.
Activation of the AAR in the liver requires the eIF2 kinase called general control nonderepressible 2 kinase (GCN2).
To what extent activation of the GCN2-eIF2-AAR is mediated by ATF4 is unknown.
Our objective and hypothesis are addressed in our aim to describe the liver response to ASNase in mice deleted for Atf4.
RNA sequencing alongside complementary biochemical approaches was performed in the livers of mice treated with eight daily injections of ASNase or saline excipient.
Differences in gene expression were evaluated.
We also explored the relationship between the different treatment groups and strains.
This research provides insight into the importance of genetic background of patients in choosing ASNase as a treatment.
نوع البيانات
أوراق مؤتمرات
رقم السجل
BIM-913097
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Baghdadi, Rana Jabir Tarish. 2018-12-31. Transcriptional profiling of livers from different strain of mice treated with Asparaginase. Scientific Conference : Depending on Scientific Research Approach to develop animal industry and overcome its Problems (6th : 2017 : al-Qadisiyah University, Iraq). . Vol. 17, no. 2 (2018), pp.125-128.a-Qadisiyah Iraq : al-Qadisiyah University College of Veterinary Medicine.
https://search.emarefa.net/detail/BIM-913097
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Baghdadi, Rana Jabir Tarish. Transcriptional profiling of livers from different strain of mice treated with Asparaginase. . a-Qadisiyah Iraq : al-Qadisiyah University College of Veterinary Medicine. 2018-12-31.
https://search.emarefa.net/detail/BIM-913097
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Baghdadi, Rana Jabir Tarish. Transcriptional profiling of livers from different strain of mice treated with Asparaginase. . Scientific Conference : Depending on Scientific Research Approach to develop animal industry and overcome its Problems (6th : 2017 : al-Qadisiyah University, Iraq).
https://search.emarefa.net/detail/BIM-913097
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر