General control nonderepressible 2 and ATF4 direct liver genes during asparaginase treatment in mice
المؤلف
al-Baghdadi, Rana Jabir Tarish
المصدر
al-Qadisiyah Journal of Veterinary Medicine Sciences
الناشر
جامعة القادسية كلية الطب البيطري
تاريخ النشر
2018-12-31
دولة النشر
العراق
عدد الصفحات
4
التخصصات الرئيسية
الملخص الإنجليزي
Asparaginase (ASNase) treatment results in synthesis of some factors such as ATF4.
The eIF2-ATF4 pathway is essential for cell survival during amino acid starvation conditions.
Activation of the AAR in liver requires the eIF2 kinase called general control nonderepressible 2 kinase (GCN2).
To what extent activation of the GCN2-eIF2-AAR is mediated by ATF4 is unknown.
Our objective and hypothesis are addressed in our aim to describe the liver response to ASNase in mice deleted for Atf4.
RNA sequencing alongside complementary biochemical approaches were performed in the livers of mice treated with eight daily injections of ASNase or saline excipient.
Cellular pathways examined in detail included the AAR.
We discovered that global hepatic gene expression patterns in Atf4 knockout mice overlapped with Gcn2 knockout mice.
Shared hepatic pathways or processes altered during ASNase included mTOR signaling, and xenobiotic metabolism.
On the other hand, loss of Atf4 during ASNase uniquely altered gene expression signatures reflecting signaling via eIF2 and ER stress.
This research provides insight into the importance of genetic background of patients in choosing ASNase as a treatment
نوع البيانات
أوراق مؤتمرات
رقم السجل
BIM-913100
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Baghdadi, Rana Jabir Tarish. 2018-12-31. General control nonderepressible 2 and ATF4 direct liver genes during asparaginase treatment in mice. Scientific Conference : Depending on Scientific Research Approach to develop animal industry and overcome its Problems (6th : 2017 : al-Qadisiyah University, Iraq). . Vol. 17, no. 2 (2018), pp.129-132.a-Qadisiyah Iraq : al-Qadisiyah University College of Veterinary Medicine.
https://search.emarefa.net/detail/BIM-913100
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Baghdadi, Rana Jabir Tarish. General control nonderepressible 2 and ATF4 direct liver genes during asparaginase treatment in mice. . a-Qadisiyah Iraq : al-Qadisiyah University College of Veterinary Medicine. 2018-12-31.
https://search.emarefa.net/detail/BIM-913100
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Baghdadi, Rana Jabir Tarish. General control nonderepressible 2 and ATF4 direct liver genes during asparaginase treatment in mice. . Scientific Conference : Depending on Scientific Research Approach to develop animal industry and overcome its Problems (6th : 2017 : al-Qadisiyah University, Iraq).
https://search.emarefa.net/detail/BIM-913100
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر