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Genotoxicity and repair capability of Mus musculus DNA following the oral exposure to tramadol
المؤلفون المشاركون
Asad, Farkhanda
Mubarak, Muhammad Sami
Qamar, Saminah
Yaqub, Sajid
Ali, Tibah
Rafiq, Malihah
Zuhur, Kashif
Ahmad, Shahzad
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 27، العدد 1 (31 يناير/كانون الثاني 2020)، ص ص. 12-17، 6ص.
الناشر
تاريخ النشر
2020-01-31
دولة النشر
السعودية
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Tramadol is an analgesic and psychoactive drug that acts primarily upon the central nervous system where it alters brain function, resulting in temporary changes in perception, mood, consciousness and behavior.
The aim of present study was to analyze the genotoxicity and repair capability of DNA after Tramadol exposure in albino mice (Mus musculus).
For this purpose, forty mice were divided equally into four groups as; a control group (without drug) and three treatment groups that were treated with three doses of Tramadol as minimum dose group, Intermediate dose group and maximum dose group, corresponding to 25 mg/kg, 50 mg/kg and 75 mg/kg of body weight respectively.
The dose was given orally for 15 days.
After 15 days peripheral blood was drawn from half mice of each group and subjected to comet assay.
While the remaining half mice were given a recovery period of 15 days and same procedure was used for blood collection and comet assay.
Significant difference in various comet parameters was observed among control and exposed groups.
Maximum damage was observed at highest concentration 75 mg/kg of Tramadol and minimum damage was observed at dose 25 mg/kg of Tramadol, while results of repaired mice group showed that repair capability of Tramadol was minor and recovery of Tramadol required a lot of time.
It can be concluded that Tramadol cause genotoxicity that is dose dependent and has low repair capability.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ali, Tibah& Rafiq, Malihah& Mubarak, Muhammad Sami& Zuhur, Kashif& Asad, Farkhanda& Yaqub, Sajid…[et al.]. 2020. Genotoxicity and repair capability of Mus musculus DNA following the oral exposure to tramadol. Saudi Journal of Biological Sciences،Vol. 27, no. 1, pp.12-17.
https://search.emarefa.net/detail/BIM-920434
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ali, Tibah…[et al.]. Genotoxicity and repair capability of Mus musculus DNA following the oral exposure to tramadol. Saudi Journal of Biological Sciences Vol. 27, no. 1 (Jan. 2020), pp.12-17.
https://search.emarefa.net/detail/BIM-920434
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ali, Tibah& Rafiq, Malihah& Mubarak, Muhammad Sami& Zuhur, Kashif& Asad, Farkhanda& Yaqub, Sajid…[et al.]. Genotoxicity and repair capability of Mus musculus DNA following the oral exposure to tramadol. Saudi Journal of Biological Sciences. 2020. Vol. 27, no. 1, pp.12-17.
https://search.emarefa.net/detail/BIM-920434
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 17
رقم السجل
BIM-920434
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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