Anti-adhesion therapy : a promising alternative in the infections treatment

الملخص EN

Objective: Antibiotic resistance (AR) represents one of the most important health problemsworldwide due to the fact that it significantly lowers the number of effective antibacterial agents.Many mechanisms were studied to reduce emerge of AR, one of these is the use of AntiadhesionMethods: keywords were used to search Most of the subject available articles.

Following that, agrammatical examination was done for the vocabulary associated with the literature review.Results: Anti-adhesion agents represent vital approach to stop or treat bacterial infections.

As theseagents focus on bacterial virulence and pathogenicity properties (e.g.

adhesion andcolonization).These agents considered a perfect alternative for an antibiotic, with the infectiousprocess inhibiting advantage in the first step to reduce the damage.

These agents inhibit bacteriaattachment to the surface of the host cell through interfering with the assembly of host receptor,bacteria-host cell assembly or adhesion biosynthesis.

Bacterial adhesions antibodies can preventsurface epitopes required for bacteria-host cell attachment by the application of anti-adhesionstrategy to decrease AR or reduce the need for the effective antibiotic doses .Conclusions: Anti-adhesion therapy includes efforts for preventing adherence, reducesvirulence, and biofilm formation.

These have advantages over classical antibiotics throughblocking pathogenicity without destroying bacteria and it also have a synergistic effect whenapplied with antibiotics