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Effects of atorvastatin on some inflammatory markers in patients with multiple sclerosis treated by interferon beta-1b
المؤلفون المشاركون
Uthman, Shamil Hisham
Mahmud, Farah Walid
المصدر
العدد
المجلد 14، العدد 1 (31 ديسمبر/كانون الأول 2014)، ص ص. 23-31، 9ص.
الناشر
تاريخ النشر
2014-12-31
دولة النشر
العراق
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective: To investigate the effect of Atorvastatin vs.
placebo on some inflammatory markers in patients with multiple sclerosis treated by interferone beta- 1b.To achieve the aim of this study, a randomized control comparative trial was adopted.
Patients and Methods: A total of 100 patients with multiple sclerosis were recruited and investigated for some inflammatory markers which included, interleukin-2, tumor necrosis factor-α, C-reactive protein, and erythrocyte sedimentation rate.
The patients were divided into 2 groups, namely the atorvastatin group which consisted of 50 patients and the placebo group which consisted of 50 patients.
The patient groups were followed- up for 12 weeks during which the above parameters were measured before starting therapies and at the end of the follow-up period using commercially available kits.
The patient groups were compared with the control group consisted of 50 apparently healthy subjects.
Results: The IL-2,TNF-α,CRP and ESR at baseline in both patient groups were found significantly elevated as compared with the control group ( p< 0.001) .
The use of atorvastatinhas resulted in significant decrease on the above parameters with nonsignificant effects in the placebogroup.
Atorvastatinappeared to be superior in compared with the placebo group.
Conclusion: The use of atorvastatinfor 12 weeks in patients withmultiple sclerosis treated by interferone-beta has beneficial effect on some inflammatory markers studied in this research( IL-2,TNF-α,CRP and ESR).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mahmud, Farah Walid& Uthman, Shamil Hisham. 2014. Effects of atorvastatin on some inflammatory markers in patients with multiple sclerosis treated by interferon beta-1b. Iraqi Journal of Pharmacy،Vol. 14, no. 1, pp.23-31.
https://search.emarefa.net/detail/BIM-946714
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mahmud, Farah Walid& Uthman, Shamil Hisham. Effects of atorvastatin on some inflammatory markers in patients with multiple sclerosis treated by interferon beta-1b. Iraqi Journal of Pharmacy Vol. 14, no. 1 (2014), pp.23-31.
https://search.emarefa.net/detail/BIM-946714
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mahmud, Farah Walid& Uthman, Shamil Hisham. Effects of atorvastatin on some inflammatory markers in patients with multiple sclerosis treated by interferon beta-1b. Iraqi Journal of Pharmacy. 2014. Vol. 14, no. 1, pp.23-31.
https://search.emarefa.net/detail/BIM-946714
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 29-31
رقم السجل
BIM-946714
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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