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Allelic estrogen receptor beta (ESR2) gene association with Polycystic Ovary Syndrome in unmarried Iraqi emale of Baghdad governorate
المؤلفون المشاركون
al-Jafari, Bushra Abd al-Hadi Jassam
al-Jumayli, Isam Fadil Ulwan
المصدر
Iraqi Journal of Biotechnology
العدد
المجلد 18، العدد 3 (31 ديسمبر/كانون الأول 2019)، ص ص. 26-32، 7ص.
الناشر
جامعة بغداد معهد الهندسة الوراثية و التقنيات الإحيائية للدراسات العليا
تاريخ النشر
2019-12-31
دولة النشر
العراق
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
This study was carried out in the laboratories of Institute of Genetic Engineering and Biotechnology for postgraduate Studies – University of Baghdad from 1 Novmber 2018 until May 2019, and the sample collected from several laboratories in the city of Baghdad.
The total numbers of samples are100 were collected from unmarried Iraqi female aged between (20-35) years old include (50) patients were diagnosed with polycystic ovary syndrome and (50) apparently healthy subject (control).The DNA was extracted and the electrical transfer was carried out for both groups and the ESR2 SNP (rs4986938) gene were detected by qRT-PCR.
The result showed there was significant difference between control and patients in genotypes of wild allele (GG) (64.0 vs.
48.0%, respectively; odds ratio = 0.52 ; p-value = 0.0472), and that A allele frequency was significantly increased in patients compared to control (p-value = 0.038) and the wild allele G showed a significant decreased frequency in patients (p-value = 0.038).
The findings indicate that the GA genotype of rs4986938 SNP was efficient in raising the serum amount of LH in PCOS patients relative to GG or AA genotype (P<0.05) but the distinction between GA and AA genotypes was substantial.
While the AA genotype of rs4986938 SNP was effective in increasing the serum level of FSH in PCOS patients compared GG or GA genotype (P<0.05) and both differences were highly significant.
The GA genotype of rs4986938 SNP was effective in increasing the serum level of T3 in PCOS patients compared GG or AA genotype (P<0.05), but the difference was significant between GA and AA genotypes.
This study was concluded that the mutant allele A could be associated with an increased risk to develop PCOS (Odds ratio= 1.88), while the wild allele G might have a protective effect
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Jafari, Bushra Abd al-Hadi Jassam& al-Jumayli, Isam Fadil Ulwan. 2019. Allelic estrogen receptor beta (ESR2) gene association with Polycystic Ovary Syndrome in unmarried Iraqi emale of Baghdad governorate. Iraqi Journal of Biotechnology،Vol. 18, no. 3, pp.26-32.
https://search.emarefa.net/detail/BIM-955669
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Jafari, Bushra Abd al-Hadi Jassam& al-Jumayli, Isam Fadil Ulwan. Allelic estrogen receptor beta (ESR2) gene association with Polycystic Ovary Syndrome in unmarried Iraqi emale of Baghdad governorate. Iraqi Journal of Biotechnology Vol. 18, no. 3 (Dec. 2019), pp.26-32.
https://search.emarefa.net/detail/BIM-955669
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Jafari, Bushra Abd al-Hadi Jassam& al-Jumayli, Isam Fadil Ulwan. Allelic estrogen receptor beta (ESR2) gene association with Polycystic Ovary Syndrome in unmarried Iraqi emale of Baghdad governorate. Iraqi Journal of Biotechnology. 2019. Vol. 18, no. 3, pp.26-32.
https://search.emarefa.net/detail/BIM-955669
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 32
رقم السجل
BIM-955669
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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