Effective treatments for bladder cancer affecting CXCL9 CXCL10 CXCL11 CXCR3 axis : a review
المؤلفون المشاركون
Nizari, Ali Rida
al-Ahmadi, Zahrah
Fard, Mitra Abbasi
Taghipour, Zahrah
Falahati pour, Soudeh Khanamani
Zlazad, Husayn Kharam
Hasan Sahi, Ghulam Ḥusayn
المصدر
العدد
المجلد 35، العدد 2 (31 مارس/آذار 2020)11ص.
الناشر
المجلس العماني للاختصاصات الطبية
تاريخ النشر
2020-03-31
دولة النشر
سلطنة عمان
عدد الصفحات
11
التخصصات الرئيسية
الموضوعات
الملخص EN
Bladder cancer (BC) originates mainly from the epithelial compartment of the bladder, which is defined as transitional cell carcinoma or urothelial cell carcinoma.
About 70% of patients with BC will survive five years from diagnosis.
Previous studies revealed that the immune system and its mediators, particularly chemokines, play a crucial role in modulating responses against BC.
Chemokines, which serve as chemoattractants for leukocytes, are small proteins that can initiate inflammatory and anti-inflammatory immune responses and also are associated with many aspects of both regulation and progression of mentioned responses.
Additionally, these immune mediators can interfere with the other tumor-related processes, including tumor proliferation, neovascularization, and metastases.
Among these chemokines, CXC chemokines, including CXCL9, CXCL10, and CXCL11, are recognized as the main ligands of C-X-C motif chemokine receptor 3 (CXCR3) and contribute to related immune responses after therapeutic strategies for BC.
Evidence suggests that the production of these chemokines can have two important implications.
First, these mediators can trigger the accumulation of CD8+ T cells that can contribute to the elimination of the tumor.
Secondly, the production of these chemokines by tumor tissue may trigger the migration and activation of immune cells including myeloid-derived suppressor cells and regulatory T cells, which act in favor of the tumor and its progress.
Therefore, in this review, we describe the latest therapeutic approaches based on targeting this axis’s components and subsequent immune phenomenon.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nizari, Ali Rida& al-Ahmadi, Zahrah& Hasan Sahi, Ghulam Ḥusayn& Fard, Mitra Abbasi& Taghipour, Zahrah& Falahati pour, Soudeh Khanamani…[et al.]. 2020. Effective treatments for bladder cancer affecting CXCL9 CXCL10 CXCL11 CXCR3 axis : a review. Oman Medical Journal،Vol. 35, no. 2.
https://search.emarefa.net/detail/BIM-956965
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Taghipour, Zahrah…[et al.]. Effective treatments for bladder cancer affecting CXCL9 CXCL10 CXCL11 CXCR3 axis : a review. Oman Medical Journal Vol. 35, no. 2 (Mar. 2020).
https://search.emarefa.net/detail/BIM-956965
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nizari, Ali Rida& al-Ahmadi, Zahrah& Hasan Sahi, Ghulam Ḥusayn& Fard, Mitra Abbasi& Taghipour, Zahrah& Falahati pour, Soudeh Khanamani…[et al.]. Effective treatments for bladder cancer affecting CXCL9 CXCL10 CXCL11 CXCR3 axis : a review. Oman Medical Journal. 2020. Vol. 35, no. 2.
https://search.emarefa.net/detail/BIM-956965
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-956965
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر