ytochrome P450 aromatase expression in men with urinary bladder carcinoma

الملخص EN

ABSTRACT: Cytochrome P450 Objective:The goal of this work is to study the alterations in the aromatase,and its role in pathogenicity of bladder cancer in biopsies of men who are initially diagnosed with this disease.

Methods: Immunohistochemistry staining (IHCS) was applied on biopsies taken from 42 men with bladder cancer , and other 38 benign considered as acontrol group to detect Cytochrome P450 aromatase.

Results:The results revealed a highly significant (P<0.05) level of Cytochrome P450 aromatase in patients in comparison with control group.

Conclusions:It was concluded from the results of the present study that Cytochrome P450 aromatase was good prognostic biomarker has important role in pathogenecity and progression of urinary bladder cancer in men ,and these results significantly correlate with the early stages of disease.

Recommendations : It may be recommended using of this biomarker inhibitor may be considered as a target for anticancer therapy